171670-29-4Relevant academic research and scientific papers
Efficient synthesis of rottlerin and its two subunits
Li, Yangfeng,Yu, Biao,Wang, Renxiao
supporting information, p. 1856 - 1859 (2016/04/19)
Rottlerin, a natural product isolated from Mallotus philippensis, is associated with a range of biological activities. Its chemical structure is featured by two different substituted phloroglucinol units linked by a methylene group. In this study, we accomplished a total synthesis of rottlerin using phenol-aldehyde condensation as the key reaction. By our method, gram-scale preparation of the two structural subunits was achieved, and rottlerin was obtained in a longest eight linear step with 20% overall yield. Our study provides a practical solution for obtaining the sample of rottlerin in an efficient way.
Polymer supported magnesium anthracene: application in the synthesis of benzylic Grignard reagents
Ancker, Tania R. van den,Harvey, Steven,Raston, Colin L.
, p. 35 - 46 (2007/10/02)
Reactions of polystyrene supported magnesium anthracene containing radical anion and dianion sites, 7,7', with benzylic chlorides or bromides, affords Grignard reagents, RMgX, in modest to high yields, in THF at -10 deg C to 20 deg C.Novel benzylic-type Grignard reagents prepared in high yield include those of 2,6-(dichloromethyl)pyridine, 2,6-(dibromomethyl)pyridine, 2,2',2"-trispyridylmethylchloride, 2-methoxy-3-methyl-1-benzylchloride, 2,4-dimethoxy-5-methyl-1-benzylchloride, 3,5-dimethoxy-4-methyl-1-benzylchloride, 2,4,6-trimethoxy-3-methyl-1-benzylchloride, and 2,5-dimethoxybenzylchloride.Selected allylic halides similarly yield Grignard reagents.Keywords: Polymer; Magnesium; Anthracene; Grignard Reagent; Benzylic halide; Styrene
