171671-47-9Relevant academic research and scientific papers
Design, synthesis, and evaluation of a potent mechanism-based inhibitor for the TEM β-lactamase with implications for the enzyme mechanism
Miyashita, Kazuyuki,Massova, Irina,Taibi, Pascale,Mobashery, Shahriar
, p. 11055 - 11059 (1995)
The design, synthesis, and evaluation of 6α-(hydroxymethyl)penicillanic acid (4) as a new mechanism-based inhibitor for the class A TEM-1 β-lactamase is described. The design of this compound was aided by computer modeling, using the high-resolution cryst
