Design, synthesis, and evaluation of a potent mechanism-based inhibitor for the TEM β-lactamase with implications for the enzyme mechanism

DOI: 10.1021/ja00150a003

Source and publish data:

Journal of the American Chemical Society p. 11055 - 11059 (1995)

Update date:2022-08-05

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Authors:

Miyashita, Kazuyuki

Massova, Irina

Taibi, Pascale

Mobashery, Shahriar

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Article abstract of DOI:10.1021/ja00150a003

The design, synthesis, and evaluation of 6α-(hydroxymethyl)penicillanic acid (4) as a new mechanism-based inhibitor for the class A TEM-1 β-lactamase is described. The design of this compound was aided by computer modeling, using the high-resolution cryst

Full text of DOI:10.1021/ja00150a003

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