Design, synthesis, and evaluation of a potent mechanism-based inhibitor for the TEM β-lactamase with implications for the enzyme mechanism

DOI: 10.1021/ja00150a003

Source and publish data:

Journal of the American Chemical Society p. 11055 - 11059 (1995)

Update date:2022-08-05

Topics:

Authors:

Miyashita, Kazuyuki

Massova, Irina

Taibi, Pascale

Mobashery, Shahriar

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/ja00150a003

The design, synthesis, and evaluation of 6α-(hydroxymethyl)penicillanic acid (4) as a new mechanism-based inhibitor for the class A TEM-1 β-lactamase is described. The design of this compound was aided by computer modeling, using the high-resolution cryst

Full text of DOI:10.1021/ja00150a003

Products guided by the article

Product name:p-nitrobenzyl 6α-bromo-6β-(hydroxymethyl)penicillanate

Cas No:171671-47-9

R&D Labs maybe for 171671-47-9

China Synchem Technology Co.,Ltd

website:http://www.cnsynchem.com

Contact:+86-0552-4929311

Address:No.217 Daqing Road
Yancheng Smiling Imp & Exp Co., Ltd.

Contact:+86-515-83173586

Address:Rm1207, BLD#03, Phoenix Plaza, Juheng Road, Yancheng, Jiangsu, P.R. China
Accendatech Co., LTD

Contact:+86-22-83718541

Address:32th Floor, Rongqiao Center Intersection of Changjiang Road and Nankai Six Road Nankai District Tianjin 300102, China
Shanghai Rainbow Chemistry Co., Ltd.

Contact:+86-21-64968086-5815/5812

Address:3rd floor, Building 7, 251 Faladi Road, Zhangjiang Hi-Tech Park, Pudong District, Shanghai, P.R. China
WD Silicone Co., Ltd

Contact:+86-27-87204219, +86-27-87215023

Address:2402, HuiGu Space-time Building, 8 Forest Road, East Lake Hi-Tech Development Zone

Relevant to this article

Poly(pyrazol-1-ylmethyl)benzenes: New Multidentate Ligands

Doi:10.1071/CH9951587
(1995)
Tetraethylammonium (2-Thioxo-1,3-dithiole-4,5-dithiolato-S⁴,S⁵)triphenylphosphinecopper(I)

Doi:10.1107/S0108270195002885
(1995)
Metabolic products of fungi. XXVI. Synthesis of racemic ustilaginoidin A and its related compounds. (1). Synthesis of 2.2',4.4',5.5',7.7'-octamethoxy-1.1'-binaphthalene (=product A octamethyl ether).

Doi:10.1248/cpb.15.1765
(1967)
Enantioselective alkylation of aldehydes catalyzed by new chiral diselenides

Doi:10.1016/0040-4039(95)01668-8
(1995)
Novel 2,7-dialkyl-substituted 5(S)-amino-4(S)-hydroxy-8-phenyl- octanecarboxamide transition state peptidomimetics are potent and orally active inhibitors of human renin

Doi:10.1021/jm070314y
(2007)
Reactions of α-Polyhalo Ketone Tosylhydrazones with Sulfide Ion and Primary Amines. Cyclization to 1,2,3-Thiadiazoles and 1,2,3-Triazoles

Doi:10.1246/bcsj.59.179
(1986)

Article Doi