171762-85-9

Basic information

• Product Name: 4-Amino-1-[(2R,3R,4R,5R)-5-azidomethyl-4-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidin-2-one
• Synonyms: 4-Amino-1-[(2R,3R,4R,5R)-5-azidomethyl-4-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidin-2-one
• CAS NO: 171762-85-9
• Molecular Weight: 534.69
• Mol File: 171762-85-9.mol

Chemical Properties

• CAS DataBase Reference: 4-Amino-1-[(2R,3R,4R,5R)-5-azidomethyl-4-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-1-[(2R,3R,4R,5R)-5-azidomethyl-4-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidin-2-one(171762-85-9)
• EPA Substance Registry System: 4-Amino-1-[(2R,3R,4R,5R)-5-azidomethyl-4-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidin-2-one(171762-85-9)

Safety Data

• Hazardous Substances Data: 171762-85-9(Hazardous Substances Data)

Upstream product

• 187733-72-8 1-((2R,3R,4S,5S)-4-Hydroxy-5-iodomethyl-3-methoxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione 
• 55486-09-4 2'-O-Methyl-5-methyluridine 
• 187733-73-9 5'-azido-5'-deoxy-2'-O-methyl-5-methyluridine 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 452096-06-9 1-[5-azidomethyl-4-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-tetrahydro-furan-2-yl]-5-methyl-4-[1,2,4]triazol-1-yl-1H-pyrimidin-2-one 
• 171763-28-3 1-[(2R,3R,4R,5R)-5-Azidomethyl-4-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 

Downstream Products

• 452096-04-7 C₆₃H₇₇N₆O₁₁PSi₂ 
• 197021-58-2 N-{1-[5-azidomethyl-4-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-tetrahydro-furan-2-yl]-5-methyl-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide 

Relevant articles and documents

Nucleic acid containing 3′-C-P-N-5′ ethyl phosphonamidate ester and 2′-methoxy modifications in combination; synthesis and hybridisation properties

The preparation of thymidine-thymidine and thymidine-5-methylcytidine dinucleosides containing a 3′-C-P-N-5′ ethyl phosphonamidate ester linkage, with defined phosphorus stereochemistry, in combination with a 2′-methoxy substituent in the lower sugar residue, is described. Incorporation of these dinucleosides into DNA oligonucleotides and the effect upon duplex stability with complimentary RNA is reported.

Stark erhoehte Affinitaet modifizierter Oligonucleotide mit in ihrer Konformation eingeschraenkten Furanose-Ringen fuer komplementaere RNA-Straenge

Keywords: Amide; Antisense-Oligonucleotide; Desoxyzucker; Molekular Modeling; Nucleinsaeuren