452096-06-9

Upstream product

• 288-88-0 1,2,4-Triazole 
• 171763-28-3 1-[(2R,3R,4R,5R)-5-Azidomethyl-4-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 187733-73-9 5'-azido-5'-deoxy-2'-O-methyl-5-methyluridine 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 452096-04-7 C₆₃H₇₇N₆O₁₁PSi₂ 
• 197021-58-2 N-{1-[5-azidomethyl-4-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-tetrahydro-furan-2-yl]-5-methyl-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide 
• 171762-85-9 4-Amino-1-[(2R,3R,4R,5R)-5-azidomethyl-4-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidin-2-one 

Relevant academic research and scientific papers

Nucleic acid containing 3′-C-P-N-5′ ethyl phosphonamidate ester and 2′-methoxy modifications in combination; synthesis and hybridisation properties

The preparation of thymidine-thymidine and thymidine-5-methylcytidine dinucleosides containing a 3′-C-P-N-5′ ethyl phosphonamidate ester linkage, with defined phosphorus stereochemistry, in combination with a 2′-methoxy substituent in the lower sugar residue, is described. Incorporation of these dinucleosides into DNA oligonucleotides and the effect upon duplex stability with complimentary RNA is reported.