171897-35-1

Upstream product

• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 169774-59-8 methyl (2S)-1-benzoyl-4-oxo-2-pyrrolidinecarboxylate 
• 98-88-4 benzoyl chloride 
• 31560-20-0 (2S,4R)-1-benzoyl-4-hydroxypyrrolidine-2-carboxylic acid methyl ester 
• 1499-56-5 (R)-4-hydroxy-L-proline ethyl ester 

Downstream Products

• 171897-43-1 methyl (2R,4S)-1-benzoyl-4-(4-chlorophenyl)-2-pyrrolidinecarboxylate 
• 171897-44-2 (2R,4S)-4-(4-chlorophenyl)-2-pyrrolidinecarboxylic acid 
• 171897-38-4 (2S,4R)-4-(4-chlorophenyl)-2-pyrrolidinecarboxylic acid 
• 171897-42-0 methyl (2R,4R)-1-benzoyl-4-(4-chlorophenyl)-4-hydroxy-2-pyrrolidinecarboxylate 

Relevant academic research and scientific papers

Stereospecific synthesis of (R)- and (S)-Baclofen and (R)- and (S)- PCPGABA [4-amino-2-(4-chlorophenyl)butyric acid] via (R)- and (S)-3-(4- chlorophenyl)pyrrolidines

(R)- and (S)-baclofen and (R)- and (S)-PCPGABA [4-amino-2-(4- chlorophenyl)butyric acid] were stereospecifically synthesized via (R)- and (S)-3-(4-chlorophenyl)pyrrolidines, starting from trans-4-hydroxy-L-proline. The syntheses involve two key operations