537039-44-4

Usage

Uses

Used in Pharmaceutical Industry:
[3-AMINO-5-(TRIFLUOROMETHYL)PHENYL]METHANOL is used as a building block for the synthesis of pharmaceutical drugs due to its unique molecular structure and functional groups. Its ability to be incorporated into various drug molecules makes it a valuable asset in the development of new therapeutic agents.
Used in Chemical Industry:
In the chemical industry, [3-AMINO-5-(TRIFLUOROMETHYL)PHENYL]METHANOL is used as a starting material for the synthesis of other organic compounds. Its versatile molecular structure allows for further functionalization and modification, leading to the creation of a wide range of chemical products.
Used in Medicinal Chemistry Research:
[3-AMINO-5-(TRIFLUOROMETHYL)PHENYL]METHANOL is used as a research compound for investigating its potential anti-inflammatory and analgesic properties. Its unique molecular features make it a promising candidate for the development of new drugs targeting inflammation and pain management.
Overall, [3-AMINO-5-(TRIFLUOROMETHYL)PHENYL]METHANOL is a versatile and valuable compound with a range of potential applications in the fields of medicine and chemistry, making it an important asset for researchers and industry professionals alike.

Upstream product

• 180146-66-1 (3-nitro-5-(trifluoromethyl)phenyl)methanol 
• 328-80-3 3-nitro-5-trifluoromethyl-benzoic acid 
• 22227-63-0 methyl 3-nitro-5-(trifluoromethyl)-benzoate 
• 22235-25-2 3-amino-5-trifluoromethylbenzoic acid methyl ester 

Downstream Products

• 1003843-86-4 (3-dimethylamino-5-trifluoromethyl-phenyl)-methanol 
• 954123-46-7 1‐bromo‐3‐(bromomethyl)‐5‐(trifluoromethyl)benzene 
• 954123-48-9 tert-butyl 4-((3-bromo-5-(trifluoromethyl)benzyloxy)methyl)-4-phenylpiperidine-1-carboxylate 
• 868167-58-2 [3-iodo-5-(trifluoromethyl)phenyl]methanol 
• 172023-97-1 (3‐bromo‐5‐(trifluoromethyl)phenyl)methanol 
• 868167-59-3 [3-(methylthio)-5-(trifluoromethyl)phenyl]methanol 
• 886496-87-3 (3-chloro-5-(trifluoromethyl)phenyl)methanol 

Relevant academic research and scientific papers

UREA DERIVATIVE AND USE THEREFOR

The purpose of the present invention is to provide a compound with inhibitory activity on Discoidin Domain Receptor 1. The present invention provides a urea derivative represented by the formula (I) below or a pharmaceutically acceptable salt thereof.

UREA DERIVATIVE AND USE THEREFOR

The purpose of the present invention is to provide a compound with inhibitory activity on Discoidin Domain Receptor 1. The present invention provides a urea derivative represented by the formula below or a pharmaceutically acceptable salt thereof.

Biaryls as potent, tunable dual neurokinin 1 receptor antagonists and serotonin transporter inhibitors

Depression is a serious illness that affects millions of patients. Current treatments are associated with a number of undesirable side effects. Neurokinin 1 receptor (NK1R) antagonists have recently been shown to potentiate the antidepressant e

AMINO-PIPERIDINE DERIVATIVES AS CETP INHIBITORS

The present invention provides a compound of formula (I), wherein the variants R1, R2, R3, R4, R5, R6, R7 are as defined herein, and wherein said compound is an inhibitor of CETP, and thus can be employed for the treatment of a disorder or disease mediated by CETP or responsive to the inhibition of CETP.

NK-1 AND SEROTONIN TRANSPORTER INHIBITORS

The invention encompasses compounds of Formula I, including pharmaceutically acceptable salts, their pharmaceutical compositions, and their use in treating disorders associated with an excess or imbalance of tachykinins or serotonin or both.

TRISUBSTITUTED AMINE COMPOUND

The present invention relates to a compound of the general formula (1): wherein, Y is a methylene group, and the like; A is an optionally substituted heterocyclic group, and the like; B is an optionally substituted heterocyclic group, and the like; R1 is an optionally substituted alkyl group, wherein the alkyl group further may optionally be substituted by an optionally substituted homocyclic group, and the like; and R2 is an optionally substituted amino group, and the like; or a pharmaceutically acceptable derivative thereof, which has an inhibitory activity against cholesteryl ester transfer protein (CETP), thereby being useful for prophylaxis and/or treatment of arteriosclerotic diseases, hyperlipemia or dyslipidemia, and the like.

A PROCESS FOR PREPARING TETRAHYDROQUINOLINE DERIVATIVES

The present invention is to provide a process for preparing optically active tetrahydroquinoline derivatives which can be used for the treatment and/or prevention of diseases such as arteriosclerotic diseases, dyslipidemia and the like, and a process for preparing synthetic intermediates thereof. Specifically, (2R,4S)-2-ethyl-6-trifluoromethyl-1,2,3,4-tetrahydroquinolin-4-ylamine or a salt thereof is prepared with fewer steps without using an optical resolution, and the optically active tetrahydroquinoline derivatives are obtained from the amine compound.

CETP INHIBITORS

Compounds of Formula (I), including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compounds of Formu