172162-01-5Relevant academic research and scientific papers
Oxindole-based intraocular pressure reducing agents
Zaryanova, Ekaterina V.,Lozinskaya, Nataly A.,Beznos, Olga V.,Volkova, Maria S.,Chesnokova, Nataly B.,Zefirov, Nikolay S.
, p. 3787 - 3793 (2017)
The study represents the new findings at the crossroads of chemistry and medicine, particularly between medicinal and organic chemistry and ophthalmology. In this work we describe how the chemical reactivity of indolinone scaffold may be used to create small molecule ligands with strong biological response comparable with and larger than that of endogenous hormone. The synthesis of oxindole-based melatonin and 5-methoxycarbonylamino-N-acetyltryptamine (5-MCA-NAT) analogues was proposed and their ability to influence intraocular pressure (IOP) was studied in vivo. Time-dependent study revealed the prolonged effect (more than 6?h) of the lead-compound. This effect in combination with high IOP reducing effect (41?±?6%) in low concentrations of the active compound (0.1?wt%) and with high water solubility represents a great potential of low-cost oxindole derivatives as potent antiglaucoma agents.
DIHYDROOROTATE DEHYDROGENASE INHIBITORS
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Page/Page column 67, (2010/11/03)
The invention relates to compounds of formula (I) wherein R1, R2, X1, X2, Y, Ra, Rb, Q have the meanings given in claim 1. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis and also in the treatment of cancer disorders.
Induction of a ferroelectric S(C)* liquid crystal phase by an atropisomeric dopant derived from 4,4'-dihydroxy-2,2'-dimethyl-6,6'-dinitrobiphenyl
Yang,Campbell,Birch,Williams,Lemieux
, p. 9557 - 9561 (2007/10/03)
We report the induction of a ferroelectric S(C)* phase in two S(C) liquid crystal hosts using a novel chiral dopant (-)-1 that incorporates an atropisomeric core derived from 4,4'-dihydroxy-2,2'-dimethyl-6,6'-dinitrobiphenyl. The racemic dopant was synthe
Synthesis & characterization of C2-symmetric biphenyls as novel dopants for induced ferroelectric liquid crystal phases
Yang,Lemieux
, p. 247 - 253 (2007/10/02)
We report the synthesis of novel rod-like chiral dopants bearing a C2-symmetric biphenyl core with a large transverse dipole moment, and the induction of a FLC phase upon doping of such compounds into a SC host.
