1722-62-9

Basic information

• Product Name: Mepivacaine hydrochloride
• Synonyms: Mepivacaine Hydrochloride (200 mg);Ropivacaine base Mepivacaine HCL;Mepivacaine hydrochloride, >=99%;(1-methyl-dl-piperidine-2-carboxylicacid)-2,6-dimethylanilidehydrochloride;1-methyl-2’,6’-pipecoloxylididehydrochloride;6’-pipecoloxylidide,1-methyl-2monohydrochloride;carbocainehydrochloride;dl-1-methyl-2’,6’-pipecoloxylididehydrochloride
• CAS NO: 1722-62-9
• Molecular Formula: C₁₅H₂₂N₂O*ClH
• Molecular Weight: 282.81
• EINECS: 217-023-9
• Product Categories: Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Analgesic series;Sodium channel;Amines;Aromatics
• Mol File: 1722-62-9.mol
• Article Data: 0

Chemical Properties

• Melting Point: 255-257°C (dec.)
• Boiling Point: 383.1 °C at 760 mmHg
• Flash Point: 185.5 °C
• Appearance: white to beige/
• Vapor Pressure: 4.52E-06mmHg at 25°C
• Storage Temp.: Refrigerator
• Solubility: H2O: soluble20mg/mL, clear
• CAS DataBase Reference: Mepivacaine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Mepivacaine hydrochloride(1722-62-9)
• EPA Substance Registry System: Mepivacaine hydrochloride(1722-62-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 22-24/25
• RIDADR: UN 2811 6.1 / PGIII
• RTECS: TK6475000
• Hazardous Substances Data: 1722-62-9(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 1722-62-9 differently. You can refer to the following data:
1. anesthetic (local)
2. Mepivacaine hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography.
3. An anti-inflammatory and analgesic

Definition

ChEBI: The hydrochloride salt of mepivacaine. It is used as a local anaesthetic.

Brand name

Arestocaine Hydrochloride (Solvay Pharmaceuticals); Carbocaine (Hospira); Isocaine Hydrochloride(Novocol); Polocaine (AstraZeneca); Polocaine (Dentsply); Scandonest (Deproco).

Biological Functions

Mepivacaine hydrochloride (Carbocaine) is longer acting than lidocaine and has a more rapid onset of action (3–5 minutes). Topical application is not effective. It has been widely used in obstetrics, but its use has declined recently because of the early transient neurobehavioral effects it produces. Adverse reactions associated with mepivacaine are generally similar to those produced by other local anesthetics. It can be used with epinephrine or levonordefrin (dental use only).

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Mepivacaine hydrochloride is a local anesthetic that is related chemically and pharmacologically to the amide-type local anesthetics. It is often administered via local infiltration, peripheral nerve block, etc.

Biochem/physiol Actions

Local anesthetic. Reversibly blocks transient Na+ inward current, as well as the steady-state K+ outward current. Blocks tandem pore (TASK) and Kv1.5, potassium channels in model systems.

Safety Profile

skin irritant. Questionable carcinogen with

InChI:InChI=1/C15H22N2O.ClH/c1-11-7-6-8-12(2)14(11)16-15(18)13-9-4-5-10-17(13)3;/h6-8,13H,4-5,9-10H2,1-3H3,(H,16,18);1H

Synthetic route

potassium acesulfame (55589-62-3) + mepivacaine hydrochloride (1722-62-9) → mepivacaine acesulfamate

Conditions	Yield
In acetonitrile at 50℃; for 4h; Sonication;	97%

saccharin sodium salt (128-44-9) + mepivacaine hydrochloride (1722-62-9) → mepivacaine saccharinate

Conditions	Yield
In acetonitrile at 50℃; for 4h; Sonication;	95%

mepivacaine hydrochloride (1722-62-9) + sodium hydrogencarbonate (144-55-8) + methyl iodide (74-88-4) → 2-{[(2,6-Dimethylphenyl)amino]carbonyl}-1,1-dimethylpiperidinium iodide (345261-08-7)

Conditions	Yield
In dichloromethane; water	80%

Downstream Products

• 345261-08-7 2-{[(2,6-Dimethylphenyl)amino]carbonyl}-1,1-dimethylpiperidinium iodide