172219-25-9

Upstream product

• 148319-23-7 (+/-)-1-(2-hydroxyethyl)-3-piperidinecarboxylic acid ethyl ester 
• 172219-24-8 1-chloro-4-(chloro(4-iodophenyl)methyl)benzene 
• 71962-74-8 Ethyl nipecotate 
• 1711-02-0 4-iodobenzoic acid chloride 
• 172219-28-2 (4-chlorophenyl)(4-iodophenyl)methanol 
• 108-90-7 chlorobenzene 
• 99847-42-4 (4-chlorophenyl)(4-iodophenyl)methanone 

Downstream Products

• 172219-26-0 <2-<(4-chlorophenyl)(4-iodophenyl)>methoxyethyl>-1-piperidine-3-carboxylic acid 

Relevant academic research and scientific papers

Synthesis of [2-{(4-chlorophenyl)(4-[125I]iodophenyl)} methoxyethyl]-1-piperidine-3-carboxylic acid, [125I]CIPCA: A potential radiotracer for GABA uptake sites

The synthesis of racemic [2-{(4-Chlorophenyl)(4-iodophenyl)} methoxyethyl]-1-piperidine-3-carboxylic acid, (CIPCA) and its radioiodinated analog [125]CIPCA is described. CIPCA was synthesized from 4-iodobenzoyl chloride in five steps in 16% overall yield. Ammonium sulfate catalyzed solid-state isotopic exchange of CIPCA with Na125I provided [125I]CIPCA in 34% isolated radiochemical yield at a specific activity of 118 Ci/mmol. [125I]CIPCA demonstrated moderate brain extraction and good in vivo radiostability in preliminary biodistribution studies conducted in CD-1 mice. [125I]CIPCA is a potentially useful radiotracer for study of the GABA uptake system.