172226-20-9Relevant academic research and scientific papers
Asymmetric, stereocontrolled total synthesis of paraherquamide A
Williams, Robert M.,Cao, Jianhua,Tsujishima, Hidekazu,Cox, Rhona J.
, p. 12172 - 12178 (2003)
The first total synthesis of paraherquamide A, a potent anthelmintic agent isolated from various Penicillium sp. with promising activity against drug-resistant intestinal parasites, is reported. Key steps in this asymmetric, stereocontrolled total synthesis include a new enantioselective synthesis of (α-alkylated-β-hydroxyproline derivatives to access the substituted proline nucleus and a highly diastereoselective intramolecular S N2′ cyclization to generate the core bicyclo[2.2.2]diazaoctane ring system.
