172287-82-0Relevant academic research and scientific papers
5-Arylthio-Substituted 2-Amino-4-oxo-6-methylpyrrolopyrimidine Antifolates as Thymidylate Synthase Inhibitors and Antitumor Agents
Gangjee, Aleem,Devray, Rajesh,McGuire, John J.,Kisliuk, Roy L.
, p. 4495 - 4502 (1995)
Classical antifolate inhibitors of thymidylate synthase (TS) often require the reduced folate uptake system in order to exert their antitumor effects.In addition, these analogues are polyglutamylated via the enzyme folylpoly-γ-glutamate synthetase (FPGS),
