5-Arylthio-Substituted 2-Amino-4-oxo-6-methylpyrrolopyrimidine Antifolates as Thymidylate Synthase Inhibitors and Antitumor Agents

DOI: 10.1021/jm00022a015

Source and publish data:

Journal of Medicinal Chemistry p. 4495 - 4502 (1995)

Update date:2022-08-04

Topics:

Authors:

Gangjee, Aleem

Devray, Rajesh

McGuire, John J.

Kisliuk, Roy L.

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Article abstract of DOI:10.1021/jm00022a015

Classical antifolate inhibitors of thymidylate synthase (TS) often require the reduced folate uptake system in order to exert their antitumor effects.In addition, these analogues are polyglutamylated via the enzyme folylpoly-γ-glutamate synthetase (FPGS),

Full text of DOI:10.1021/jm00022a015

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