5-Arylthio-Substituted 2-Amino-4-oxo-6-methylpyrrolopyrimidine Antifolates as Thymidylate Synthase Inhibitors and Antitumor Agents

DOI: 10.1021/jm00022a015

Source and publish data:

Journal of Medicinal Chemistry p. 4495 - 4502 (1995)

Update date:2022-08-04

Topics:

Authors:

Gangjee, Aleem

Devray, Rajesh

McGuire, John J.

Kisliuk, Roy L.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00022a015

Classical antifolate inhibitors of thymidylate synthase (TS) often require the reduced folate uptake system in order to exert their antitumor effects.In addition, these analogues are polyglutamylated via the enzyme folylpoly-γ-glutamate synthetase (FPGS),

Full text of DOI:10.1021/jm00022a015

Products guided by the article

Product name:ethyl 4-<(2-amino-6-methyl-3,4-dihydro-4-oxo-7H-pyrrolo<2,3-d>pyrimidin-5-yl)sulfanyl>benzoate

Cas No:172287-82-0

R&D Labs maybe for 172287-82-0

GN chemicals co.,ltd

Contact:86 311 85902108 / 85902109

Address:room 1001-1005 ,huanghe Road ,shijiazhuang ,China
Hangzhou LINGEBA Technology Co., Ltd.

Contact:+0086-571-87389059

Address:Office 1-913,NewYouth Plaza, GongShu Area, HangZhou,ZheJiang,P.R.China
Chengdu Chengnuo New-Tech Co., Ltd

Contact:0086-028-85749078

Address:4 Jiuyang road,Jiulong industrial port,Chengdu, China
Phantom-pharma

Contact:

Address:
Fujian Xianyangyang Biotechnology Inc.

Contact:86-593-2805888

Address:No.23 Ningchuan North Road, Ningde, Fujian, China

Relevant to this article

Oxidative addition of 2-haloalkene to zirconocene

Doi:10.1021/ja00149a040
(1995)
TFA-Mediated DMSO-Participant Sequential Oxidation/1,3-Dipolar Cycloaddition Cascade of Pyridinium Ylides for the Assembly of Indolizines

Doi:10.1021/acs.joc.8b02755
(2019)
Synthesis and β-adrenergic properties of (Z)-N-[3-(alkylamino)-2-hydroxypropylidene](aryl-methyloxy)amines: Effects of the configuration around the methyloxyiminomethyl (MOIM) double bond on the biopharmacological properties of MOIM-type β-blocking agents

Doi:10.1016/S0968-0896(98)00172-2
(1998)
Hydrogenolysis-Isomerization-Reduction of Propargyl Acetate, and Regio- and Stereoselective Hydrogenation of Dienyl Ester for the Synthesis of 1β-Methylcarbapenem Precursor

Doi:10.1246/cl.1995.1013
(1995)
Generation of polyclonal catalytic antibodies against cocaine using transition state analogs of cocaine conjugated to diphtheria toxoid

Doi:10.1248/cpb.43.1902
(1995)
1,1'-Bis(diphenylthiophosphoryl)ferrocene as a trans-Chelating Ligand in Gold(I) and Silver(I) Complexes

Doi:10.1039/DT9950003563
(1995)

Article Doi