17238-66-3

Basic information

• Product Name: 4-MORPHOLINECARBOXAMIDINE
• Synonyms: 4-MORPHOLINECARBOXAMIDINE;morpholine-4-carboxamidine;Morpholin-4-carboximidamide;4-Morpholinecarboximidamide;morpholine-4-carboximidamide sulfate;Morpholino-4-carboxaMidine
• CAS NO: 17238-66-3
• Molecular Formula: C₅H₁₁N₃O
• Molecular Weight: 129.16
• EINECS: 604-604-1
• Product Categories: pharmacetical
• Mol File: 17238-66-3.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 222.624 °C at 760 mmHg
• Flash Point: 88.44 °C
• Appearance: /
• Density: 1.358 g/cm³
• Storage Temp.: 2-8°C
• PKA: 12.19±0.20(Predicted)
• CAS DataBase Reference: 4-MORPHOLINECARBOXAMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-MORPHOLINECARBOXAMIDINE(17238-66-3)
• EPA Substance Registry System: 4-MORPHOLINECARBOXAMIDINE(17238-66-3)

Safety Data

• Hazardous Substances Data: 17238-66-3(Hazardous Substances Data)

Usage

General Description

4-Morpholinecarboxamidine is a chemical compound with the formula C5H12N4O. It is an amidine derivative of morpholine, which is a heterocyclic organic compound. 4-Morpholinecarboxamidine is used as a reagent in organic synthesis and pharmaceutical research. It has been studied for its potential antiviral and anticancer properties, and as a potential inhibitor of various enzymes. The compound has also been investigated for its potential use in the treatment of diabetes and other metabolic disorders. Its precise mechanisms of action and potential uses are still being explored through ongoing research.

InChI:InChI=1/C5H11N3O/c6-5(7)8-1-3-9-4-2-8/h1-4H2,(H3,6,7)/p+1

Upstream product

• 110-91-8 morpholine 
• 625-57-0 O-ethyl thiocarbamate 
• 5638-78-8 morpholinoformamidine hydrochloride 
• 420-04-2 CYANAMID 
• 867-44-7 S-Methylisothiourea sulfate 
• 2986-19-8 carbamimidothioic acid methyl ester 
• 38184-47-3 3,5-dimethyl-1-pyrazolylformaminidium nitrate 

Downstream Products

• 1338250-36-4 C₂₉H₂₅N₇O 
• 1338250-37-5 C₃₀H₂₇N₇O 
• 1338250-38-6 C₂₉H₂₄FN₇O 
• 1338250-39-7 C₂₉H₂₄ClN₇O 
• 787500-22-5 N-(4-methoxyphenyl)morpholine-4-carboxamidine 
• 75358-30-4 N'-(4-methylphenyl)(tetrahydro-4H-oxazine)-4-carboximidamide 
• 75358-18-8 N-phenyl-(tetrahydro-4H-1,4-oxazine)-4-carboximidamide 
• 33080-91-0 2-(morpholin-1-yl)quinazolin-4(3H)-one 
• 1169877-83-1 N-(4-cyanophenyl)morpholine-4-carboxamidine 
• 1169877-82-0 4-[(morpholine-4-carboximidoyl)amino]benzoic acid methyl ester 
• 1169877-81-9 N-(4-nitrophenyl)morpholine-4-carboxamidine 

Relevant articles and documents

BIARYL COMPOUNDS USEFUL FOR THE TREATMENT OF HUMAN DISEASES IN ONCOLOGY, NEUROLOGY AND IMMUNOLOGY

The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.

Synthesis and antitumor activities of a new series of 4,5-dihydro-1H- thiochromeno[4,3-d]pyrimidine derivatives

A new series of 4,5-dihydro-1H-thiochromeno[4,3-d ]pyrimidine derivatives have been designed and synthesized. The antitumor activities of the target compounds have been evaluated in vitro against two human cancer cell lines including A549 (human alveolar adenocarcinoma cell) and H460 (human lung cancer) by MTT assay. Most of the target compounds exhibited significant antitumor activities against A549 and H460 cancer cell lines. The most potent compound 4-(benzo[d][1,3]dioxol-5-yl)-8,9-difluoro-2-(4-methylpiperazin-1-yl)-4, 5-dihydro-1H-thiochromeno[4,3-d]pyrimidine (CH05) (IC50 = 0.44 μM, 3.07 μM) was 2.0 and 8.4 times more active than gefitinib (IC50 = 0.89 μM, 16.81 μM) against A549 and H460 cell lines, respectively.

Amidination of amines under microwave conditions using recyclable polymer-bound 1H-pyrazole-1-carboxamidine

A convenient one-step transformation of primary and secondary amines into the corresponding unprotected guanidines using 4-benzyl-3,5-dimethyl-1H- pyrazole-1-carboxamidine and its polymer-bound variant is described. The scopes and limitations of the method, the microwave-assistance of amidination as well as a recycling protocol are examined. Georg Thieme Verlag Stuttgart.