24193-00-8

Basic information

• Product Name: 2-MorpholinopyriMidine-4,6-diol
• Synonyms: 2-MorpholinopyriMidine-4,6-diol
• CAS NO: 24193-00-8
• Molecular Formula: C8H11N3O3
• Molecular Weight: 197.19124
• Mol File: 24193-00-8.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Density: 1.56±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 8.31±0.10(Predicted)
• CAS DataBase Reference: 2-MorpholinopyriMidine-4,6-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-MorpholinopyriMidine-4,6-diol(24193-00-8)
• EPA Substance Registry System: 2-MorpholinopyriMidine-4,6-diol(24193-00-8)

Safety Data

• Hazardous Substances Data: 24193-00-8(Hazardous Substances Data)

Usage

General Description

2-Morpholinopyrimidine-4,6-diol is a chemical compound with the molecular formula C6H10N2O3. It is a heterocyclic compound that contains a morpholine ring and a pyrimidine ring with a diol functional group. 2-MorpholinopyriMidine-4,6-diol has various potential applications, including as a building block in the synthesis of pharmaceuticals, agrochemicals, and other organic chemicals. It can also be used as a precursor in the production of specialty polymers and as a reagent in organic synthesis. Additionally, 2-Morpholinopyrimidine-4,6-diol has been studied for its potential biological activities and is of interest in medicinal chemistry for its potential as a drug candidate. Overall, this compound has diverse potential uses and applications in the fields of chemistry, pharmaceuticals, and materials science.

Upstream product

• 157415-17-3 Morpholine-4-carboxamidine; hydrobromide 
• 105-53-3 diethyl malonate 
• 17238-66-3 morpholine-4-carboxamidine 
• 5638-78-8 morpholinoformamidine hydrochloride 

Downstream Products

• 10397-13-4 4,6-dichloro-2-(morpholine-4-yl)pyrimidine 

Relevant articles and documents

“Doubly Orthogonal” Labeling of Peptides and Proteins

Herein, we report a cysteine bioconjugation methodology for the introduction of hypervalent iodine compounds onto biomolecules. Ethynylbenziodoxolones (EBXs) engage thiols in small organic molecules and cysteine-containing peptides and proteins in a fast and selective addition onto the alkynyl triple bond, resulting in stable vinylbenziodoxolone hypervalent iodine conjugates. The conjugation occurs at room temperature in an open flask under physiological conditions. The use of an azide-bearing EBX reagent enables a “doubly orthogonal” functionalization of the bioconjugate via strain-release-driven cycloaddition and Suzuki-Miyaura cross-coupling of the vinyl hypervalent iodine bond. We successfully applied the methodology on relevant and complex biomolecules, such as histone proteins. Through single-molecule experiments, we illustrated the potential of this doubly reactive bioconjugate by introducing a triplet-state quencher close to a fluorophore, which extended its lifetime by suppressing photobleaching. This work is therefore expected to find broad applications for peptide and protein functionalization. Understanding the molecular basis of life is essential in the search for new medicines. Chemical biology develops molecular tools for studying biological processes, setting the basis for new diagnostics and therapeutics, and relies heavily on the ability to selectively modify biomolecules. Two approaches have been especially fruitful: (1) selective modification of natural biomolecules and (2) selective reaction between non-natural functionalities in the presence of biomolecules (the so-called orthogonal bioconjugation). In our work, we contribute to both by transferring highly reactive hypervalent iodine reagents to cysteine residues in proteins and peptides. The obtained bioconjugates retain the reactive hypervalent bonds, which can be selectively functionalized via a metal-mediated reaction. Combined with a traditional azide tag, our approach allows a doubly orthogonal functionalization of biomolecules and is hence expected to be highly useful in chemical biology. Chemical biology develops molecular tools for studying biological processes, setting the basis for new diagnostics and therapeutics, and relies heavily on the ability to modify selectively biomolecules. In our work, we introduce hypervalent iodine bonds into peptides and proteins, via functionalization of cysteine, by using unique cyclic reagents developed in our group. The hypervalent bond can then be selectively modified in the presence of both natural and synthetic functional groups, opening new opportunities for applications in chemical biology.

Synthesis and in vitro and in vivo evaluation of phosphoinositide-3-kinase inhibitors

Phospoinositide-3-kinases (PI3K) are important oncology targets due to the deregulation of this signaling pathway in a wide variety of human cancers. A series of 2-morpholino, 4-substituted, 6-(3-hydroxyphenyl) pyrimidines have been reported as potent inh

ANTIVIRAL PYRIMIDINES

Disclosed herein are novel compounds comprising substituted pyrimidines, pyrazolopyrimtdines, and imidazolopyrimidines, the syntheses thereof, and compositions thereof, including pharmaceutical compositions, comprising the novel pyrimidines, pyrazolopyrimtdines, imidazolpyrimidines and related compounds. Such compounds function to inhibit entry of viruses of the Flaviviridae family, including Hepatitis C virus (HCV), into cells that are susceptible to virus infection. These compounds are useful for the treatment, therapy and/or prophylaxis of viral diseases and infection, including HCV infection.