172477-88-2Relevant academic research and scientific papers
Monocyclic Analogues of the μ-Opioid Agonist 3,8-Diazabicyclooctanes: Synthesis, Modeling, and Activity
Barlocco, Daniela,Villa, Stefania,Fratta, Walter,Fadda, Paola,Colombo, Diego,Toma, Lucio
, p. 11547 - 11556 (2007/10/02)
Several monocyclic derivatives structurally related to the μ-opioid agonist 3-cinnamyl-8-propionyl-3,8-diazabicyclooctane have been synthesized and tested in binding studies using the μ-selective 3H-DAMGO as ligand.Modeling studies have been performed on the same compounds in order to explain the observed lack of affinity towards μ-opioid receptors.
