151265-01-9

Basic information

• Product Name: (S)-1-benzyl-pyrrolidine-2-carboxylic acid methylamide
• Synonyms: (S)-1-benzyl-pyrrolidine-2-carboxylic acid methylamide
• CAS NO: 151265-01-9
• Molecular Weight: 218.299
• Mol File: 151265-01-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-1-benzyl-pyrrolidine-2-carboxylic acid methylamide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-benzyl-pyrrolidine-2-carboxylic acid methylamide(151265-01-9)
• EPA Substance Registry System: (S)-1-benzyl-pyrrolidine-2-carboxylic acid methylamide(151265-01-9)

Safety Data

• Hazardous Substances Data: 151265-01-9(Hazardous Substances Data)

Upstream product

• 955-40-8 N-benzyl-L-proline ethyl ester 
• 74-89-5 methylamine 
• 67-56-1 methanol 

Downstream Products

• 172587-65-4 (S)-1-benzyl-2-methylaminomethyl-pyrrolidine 
• 172477-90-6 (S)-1-benzyl-2-<(t-butyloxycarbonyl)methylaminomethyl>-pyrrolidine 
• 172477-88-2 (S)-1-benzyl-2-methylpropionylaminomethyl-pyrrolidine 
• 172477-91-7 (S)-2-<(t-butyloxycarbonyl)methylaminomethyl>-pyrrolidine 

Relevant articles and documents

Chirospecific and subtype selective dopamine receptor binding of heterocyclic methoxynaphthamide analogs

Employing the D3 and D4 selective methoxynaphthalines nafadotride and FAUC 182, respectively, as lead compounds, the pyrazolo[1,5-a]pyridine-3-carboxamides of type 1a and 2a as well as their 2-substituted regioisomers 1b and 2b were synthesized when following an ex-chiral pool approach. Dopamine receptor binding studies involving the target compounds (1a,b, 2a,b) and the respective optical antipodes ent-1a,b and ent-2a,b revealed the heterocyclic carboxamide 2a as a strong and selective D4 ligand (Ki = 8.6 nM). According to a mitogenesis assay, 2a shows D4 partial agonist effects (29%, EC50 = 6.7 nM) and, thus, might be of interest for the treatment of sexual dysfunction.