172516-14-2

Upstream product

• 69739-34-0 t-butyldimethylsiyl triflate 
• 167892-85-5 (4R,6S)-6-(tert-Butyl-diphenyl-silanyloxy)-oct-7-en-1-yn-4-ol 
• 1040390-31-5 (3S)-3-hydroxy-4-pentenoic acid tert-butyl ester 
• 172516-15-3 (3S)-3-acetoxy-4-pentenoic acid tert-butyl ester 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 172516-16-4 (S)-3-(tert-Butyl-diphenyl-silanyloxy)-pent-4-enoic acid tert-butyl ester 
• 172516-17-5 (S)-3-((tert-butyldiphenylsilyl)oxy)pent-4-enal 
• 122763-67-1 tert-butyl 3-hydroxypent-4-enoate 

Downstream Products

• 172516-18-6 (5R,7S)-5-(tert-Butyl-dimethyl-silanyloxy)-7-(tert-butyl-diphenyl-silanyloxy)-non-8-en-2-yn-1-ol 
• 172516-19-7 (Z)-(5S,7S)-5-(tert-Butyl-dimethyl-silanyloxy)-7-(tert-butyl-diphenyl-silanyloxy)-3-iodo-nona-2,8-dien-1-ol 

Relevant academic research and scientific papers

A chemoenzymatic synthesis of A-ring key-intermediates for 1 α,25-dihydroxyvitamin D3 and analogues

A short and practical synthesis of the 1,7-enyne A-ring intermediate and of Uskokovic's phosphine-oxide precursor is described starting from the aldol product of acrolein with t-butyl acetate. Enantiopure βhydroxy ester is obtained upon lipase-catalyzed resolution.