172648-09-8

Basic information

• Product Name: 1H-Imidazo[4,5-b]pyridine-2-methanol, 5-chloro-
• CAS NO: 172648-09-8
• Molecular Formula: C7H6ClN3O
• Molecular Weight: 183.597
• Mol File: 172648-09-8.mol

Chemical Properties

• CAS DataBase Reference: 1H-Imidazo[4,5-b]pyridine-2-methanol, 5-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazo[4,5-b]pyridine-2-methanol, 5-chloro-(172648-09-8)
• EPA Substance Registry System: 1H-Imidazo[4,5-b]pyridine-2-methanol, 5-chloro-(172648-09-8)

Safety Data

• Hazardous Substances Data: 172648-09-8(Hazardous Substances Data)

Usage

Potential biological activities

anti-inflammatory, antiviral, and antibacterial properties
Valuable building block for the synthesis of pharmacologically active compounds
Possible applications in material science and organic chemistry

Upstream product

• 40851-95-4 6-chloropyridine-2,3-diamine 
• 79-14-1 glycolic Acid 
• 27048-04-0 2-amino-6-chloro-3-nitropyridine 
• 38875-53-5 5-bromo-pyridine-2,3-diamine 
• 172648-36-1 3-amino-6-benzyloxy-2-methylaminopyridine 
• 148433-49-2 3-amino-6-ethoxy-2-methylaminopyridine 
• 172648-43-0 3-amino-6-isopropxy-2-methylaminopyridine 
• 25710-20-7 5-chloro-2,3-diaminopyridine 

Downstream Products

• 1383050-91-6 5-chloro-2-(trityloxymethyl)-1H-imidazo[4,5-b]pyridine 
• 1383050-93-8 C₃₅H₃₆ClN₃O₃ 
• 1383050-92-7 4-(5-chloro-2-(trityloxymethyl)-1H-imidazo[4,5-b]pyridin-1-yl)butyl pivalate 
• 172648-11-2 5-[4-(5-chloro-3-methyl-3H-imidazo[4,5-b]pyridin-2-ylmethoxy)benzyl]-3-triphenylmethylthiazolidine-2,4-dione 

Relevant articles and documents

SPIRO UREA COMPOUNDS AS RSV ANTIVIRAL COMPOUNDS

The invention concerns novel substituted spiro urea azetidinyl or piperidinyl compounds of formula (I) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention furth

AZABENZIMIDAZOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS

A compound satisfying formula I, a prodrug, N-oxide, addition salt, quaternary metal complex, or a stereochemically isomeric form thereof; (formula I) compositions contain these compounds as active ingredient and processes for preparing these compounds and compositions.

Molecular design, synthesis, and hypoglycemic activity of a series of thiazolidine-2,4-diones

A series of imidazopyridine thiazolidine-2,4-diones were designed and synthesized from their corresponding pyridines. These compounds represent conformationally restricted analogues of the novel hypoglycemic compound rosiglitazone (5). The series was evaluated for its effect on insulin-induced 3T3-L1 adipocyte differentiation in vitro and its hypoglycemic activity in the genetically diabetic KK mouse in vivo. The structure-activity relationships are discussed. On the basis of the in vivo potency, 5-[4-(5-methoxy-3-methyl-3H-imidazo[4,5-b]pyridin-2-ylmethoxy)ben zyl]thiazolidine-2,4-dione (19a) was selected as the candidate for further studies in a clinical setting.

Heterocyclic compounds having anti-diabetic activity and their use

Compounds of formula (I): STR1 [wherein: X represents an unsubstituted or substituted indolyl, indolinyl, azaindolyl, azaindolinyl, imidazopyridyl or imidazopyrimidinyl group; Y represents an oxygen or sulfur atom; Z represents a 2,4-dioxothiazolidin-5-ylidenylmethyl, 2,4-dioxothiazolidin-5-ylmethyl, 2,4-dioxooxazolidin-5-ylmethyl, 3,5-dioxooxadiazolidin-2-ylmethyl or N-hydroxyureidomethyl group; R represents a hydrogen atom, an alkyl group, an alkoxy group, a halogen atom, a hydroxy group, a nitro group, an aralkyl group or a unsubstituted or substituted amino group; and m is an integer of from 1 to 5] have hypoglycemic and anti-diabetic activities.