172734-71-3

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 172734-70-2 (S)-(3-(3,4-dichlorophenyl)-3-(3-hydroxypropyl)piperidin-1-yl)(phenyl)methanone 

Downstream Products

• 172734-92-8 osanetant 
• 188916-67-8 [(S)-3-(3,4-Dichloro-phenyl)-3-(3-iodo-propyl)-piperidin-1-yl]-phenyl-methanone 

Relevant academic research and scientific papers

Azetidinylpropylpiperidine derivatives, intermediates and use as tachykinin antagonists

Compounds of the formula (I): where X1, A, Ar1, X and R are as defined in the specification, and pharmaceutically-acceptable salts thereof, are new, and are useful as tachykinin inhibitors which act at the NK1, NK2and NK3receptors or a combination of two or more thereof.

A practical and scalable synthesis of SR 142801, a tachykinin NK3 antagonist

A practical and scalable total synthesis of tachykinin NK3 receptor antagonist SR 142801, (R)-N-[1-[3-[1-benzoyl-3-(3,4-dichlorophenyl)-3-piperidinyl]propyl]-4-phenyl-4 -piperidinyl]-N-methyl acetamide 1 is described. The absolute configuration of the key intermediate 7 was determined by single crystal X-ray crystallography, on the basis of which, the absolute configuration of SR 142801 should be (R)-(+), instead of the recently reported (S)-(+).