17279-41-3

Basic information

• Product Name: (S)-1-(3,4-DIMETHOXYPHENYL) 2-PROPANAMINE
• Synonyms: (S)-1-(3,4-DIMETHOXYPHENYL)-2-AMINOPROPANE;(S)-1-(3,4-DIMETHOXYPHENYL) 2-PROPANAMINE;(S)-1-(3,4-DiMethoxyphenyl)propan-2-aMine;(+)-1-(3,4-Dimethoxyphenyl)-2-aminopropane;(S)-3,4-Dimethoxyamphetamine
• CAS NO: 17279-41-3
• Molecular Formula: C₁₁H₁₇NO₂
• Molecular Weight: 195.26
• Mol File: 17279-41-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 288.967 °C at 760 mmHg
• Flash Point: 139.809 °C
• Appearance: /
• Density: 1.023 g/cm³
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.512
• CAS DataBase Reference: (S)-1-(3,4-DIMETHOXYPHENYL) 2-PROPANAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-(3,4-DIMETHOXYPHENYL) 2-PROPANAMINE(17279-41-3)
• EPA Substance Registry System: (S)-1-(3,4-DIMETHOXYPHENYL) 2-PROPANAMINE(17279-41-3)

Safety Data

• Hazardous Substances Data: 17279-41-3(Hazardous Substances Data)

Usage

General Description

(S)-1-(3,4-Dimethoxyphenyl) 2-propanamine, also known as methamphetamine, is a powerful central nervous system stimulant. It is a synthetic drug that acts on the brain's dopamine and norepinephrine systems, producing feelings of heightened energy, alertness, and euphoria. Methamphetamine is highly addictive and can have severe negative effects on the body, including rapid heart rate, increased blood pressure, and damage to the brain and other organs. It is often abused for its stimulating and euphoric effects and is classified as a Schedule II controlled substance due to its high potential for abuse and addiction. It is illegal to possess, produce, or distribute methamphetamine without a valid prescription.

InChI:InChI=1/C11H17NO2/c1-8(12)6-9-4-5-10(13-2)11(7-9)14-3/h4-5,7-8H,6,12H2,1-3H3/t8-/m0/s1

Upstream product

• 91-16-7 1,2-dimethoxybenzene 
• 120-26-3 2-(3,4-dimethoxyphenyl)-1-methylethylamine 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 121-33-5 vanillin 
• 93-15-2 1,2-dimethoxy-4-(2-propenyl)benzene 
• 776-99-8 3,4-dimethoxyphenylacetone 
• 97-53-0 4-allylguaiacol 
• 97590-48-2 (S)-N-(trifluoroacetyl)-α-amino-3',4'-dimethoxypropiophenone 
• 186581-53-3 diazomethane 
• 2410-01-7 (+)(L)-2-<3,4-Dihydroxy-phenyl>-1-methyl-aethylamin 
• 97589-57-6 (S)-2--1-(3,4-dimethoxyphenyl)propane 

Downstream Products

• 94564-14-4 (S)-1-<2-(3,4-Dimethoxyphenyl)-1-methylethyl>pyrimidin-2,4,6(1H,3H,5H)-trion 

Relevant articles and documents

Transaminase-mediated synthesis of enantiopure drug-like 1-(3′,4′-disubstituted phenyl)propan-2-amines

Transaminases (TAs) offer an environmentally and economically attractive method for the direct synthesis of pharmaceutically relevant disubstituted 1-phenylpropan-2-amine derivatives starting from prochiral ketones. In this work, we report the application of immobilised whole-cell biocatalysts with (R)-transaminase activity for the synthesis of novel disubstituted 1-phenylpropan-2-amines. After optimisation of the asymmetric synthesis, the (R)-enantiomers could be produced with 88-89% conversion and >99% ee, while the (S)-enantiomers could be selectively obtained as the unreacted fraction of the corresponding racemic amines in kinetic resolution with >48% conversion and >95% ee. This journal is

Enantiomeric separation of Novel Psychoactive Substances by capillary electrophoresis using (+)-18-crown-6-tetracarboxylic acid as chiral selector

In the recent years, hundreds of Novel Psychoactive Substances (NPS) have entered both the European and the global drug market. These drugs, which are mainly used for recreational matters, have caused serious social problems. Every year, the spectrum of these misused drugs is enlarged by new derivatives, which are produced by modifications of basic structures of already well-known substances. Additionally, a lot of them possess a stereogenic center which leads to 2 enantiomeric forms. The fact that the pharmacological effects and potencies of the enantiomers of these chiral NPS may differ can be assumed from a broad spectrum of active pharmaceutical ingredients. For this reason, analytical method development regarding enantiomeric separation for these classes of substances is of great pharmaceutical and medical interest. The aim of this work was to create an easy-to-prepare chiral capillary electrophoresis method for the enantioseparation of NPS which contains a primary amino group by means of (+)-18-crown-6-tetracarboxylic acid as chiral selector. Novel Psychoactive Substances were purchased at various Internet stores or represent samples seized by Austrian police. The effects of selector concentration, the electrolyte composition, and the addition of organic modifiers to the background electrolyte on enantioseparation were investigated. Under optimized conditions, the use of 20-mM (+)-18-crown-6-tetracarboxylic acid, 10-mM Tris, and 30-mM citric acid buffer at pH 2.10 turned out to be effective. Fifteen of 24 tested NPS were resolved in their enantiomers within 15?minutes. It was found that all NPS were traded as racemic mixtures.

Asymmetric synthesis of phenylisopropylamines

The synthesis of enantiomers of a series of methoxy- and alkyl- substituted phenylisopropylamines is described. The synthesis comprises reducing the imines, formed by the reaction of appropriate phenylacetones with either (+)- or (-)-α-methylbenzylamine, by low-pressure reduction techniques, and subsequently subjecting the optically active N-(α-phenethyl)phenylisopropylamine derivative to hydrogenolysis. The hydrogenolysis products are characterized by enantiomeric purities in the range of 96 - 99%. Yields of products are approximately 60%.