172965-84-3Relevant academic research and scientific papers
'One-pot' methylation of Fmoc amino acids
Luke, Richard W. A.,Boyce, Patrick G. T.,Dorling, E. Kate
, p. 263 - 266 (1996)
We report here a convenient method for the conversion of Fmoc amino acids to their N-methylated derivatives. The method involves reaction with formaldehyde and then reduction with triethylsilane (TES). The method is particularly attractive in that the alkylation and reduction are carried out in situ and the reaction sequence and purification of product can readily be carried out in one day. A further advantage is that the method is not restricted to α-amino acids.
Constrained β-alanine based GpIIb/IIIa antagonists
Klein, Scott I.,Czekaj, Mark,Molino, Bruce F.,Valeria, Chu
, p. 1773 - 1778 (2007/10/03)
The concepts of centrally constrained and peptide based fibrinogen receptor antagonists have been successfully combined into a single series of analogs which have been demonstrated to be potent inhibitors of platelet aggregation.
