374071-91-7Relevant academic research and scientific papers
Bismuth nitrate-promoted disproportionative condensation of indoles with cyclohexanone: A new-type azafulvenium reactivity of indole
Kilic,Bayindir,Erdogan,Agopcan Cinar,Konuklar,Bali,Saracoglu,Aviyente
, p. 9674 - 9687 (2017/09/18)
The indole nucleus is a privileged heterocyclic scaffold, which is present in several natural and synthetic compounds. New synthetic strategies to access functionalized indoles have therefore attracted the attention of both synthetic and medicinal chemists over the decades. In this study, the bismuth nitrate-promoted disproportionative condensation of indoles with cyclohexanone in one pot, to yield C3-cyclohexyl substituted indoles and 1,3-di(1H-indol-3-yl)benzene derivatives is reported for the first time. Using 3-methylindole with cyclopentanone, cyclohexanone, and cycloheptanone results in new and different synthetic pathways. The plausible reaction mechanisms are presented and supported with DFT (M06-2X/6-31+G(d,p)) calculations.
Palladium-catalyzed benzothieno[2,3-b]indole formation via dehydrative-dehydrogenative double C-H sulfuration using sulfur powder, indoles and cyclohexanones
Liao, Yunfeng,Peng, Yi,Qi, Hongrui,Deng, Guo-Jun,Gong, Hang,Li, Chao-Jun
, p. 1031 - 1034 (2015/01/16)
Palladium-catalyzed C-S bond formation via dehydrative-dehydrogenative double C-H sulfuration using sulfur powder is described. The dehydrogenated intermediates of cyclohexanones can be trapped to act as efficient aryl sources under an oxygen atmosphere. This procedure provides a novel approach for the preparation of benzothieno[2,3-b]indoles. This journal is
Palladium-catalyzed intermolecular C3 alkenylation of indoles using oxygen as the oxidant
Chen, Wen-Liang,Gao, Ya-Ru,Mao, Shuai,Zhang, Yan-Lei,Wang, Yu-Fei,Wang, Yong-Qiang
supporting information, p. 5920 - 5923 (2013/02/22)
A general and efficient palladium-catalyzed intermolecular direct C3 alkenylation of indoles using oxygen as the oxidant has been developed. The reaction is of complete regio- and stereoselectivity. All products are E-isomers at the C3-position, and no Z-
