172983-88-9

Upstream product

• 536-38-9 4-chlorobenzoylmethyl bromide 
• 100-61-8 N-methylaniline 
• 1073-67-2 4-vinylbenzyl chloride 
• 172983-97-0 1-(4-Chloro-phenyl)-2-[(2-iodo-phenyl)-methyl-amino]-ethanone 

Downstream Products

• 107915-10-6 3-(4-chlorophenyl)-1-methyl-1H-indole 
• 5905-11-3 2-(4-chlorophenyl)-1-methyl-2-phenyl-1H-indole 
• 1211-35-4 2-(4-chlorophenyl)-1H-indole 
• 93-61-8 N-methyl-N-phenylformamide 
• 74-11-3 para-chlorobenzoic acid 
• 1375476-73-5 1-(4-chlorophenyl)-2-(1H-indol-3-yl)ethane-1,2-dione 
• 1476035-09-2 1-(4-chlorophenyl)-2-(2-phenyl-1H-indol-3-yl)ethane-1,2-dione 
• 88097-40-9 3-(4-chlorophenyl)-3-hydroxy-1-methylindolin-2-one 
• 1127405-07-5 1-(4-chloro-phenyl)-2-(morpholin-4-yl)ethane-1,2-dione 

Relevant academic research and scientific papers

N-(p-Chlorobenzoyl)-N-methylaniline

The crystal and molecular structure of the title compound [alternative name: p-chlorophenyl (N-methylanilino)methyl ketone], C15H14ClNO, has been determined by X-ray crystallography. There are two independent molecules in the asymmet

N-Bromosuccinimide promoted and base switchable one pot synthesis of α-imido and α-amino ketones from styrenes

An N-Bromosuccinimide (NBS) promoted one pot strategy for the synthesis of α-amino functionalized aryl ketones starting from commercially available styrenes has been developed. NBS participates in multiple tasks, such as bromonium ion formation, oxidation of bromohydrin and providing a nucleophilic nitrogen source. The reaction can easily be switched between α-imido and α-amino ketones by the choice of base. This one pot strategy was successfully applied for the synthesis of psychoactive drug candidates, amfepramone, mephedrone and 4-MEC.

Construction of indole skeletons by sequential actions of sunlight and rhodium on α-aminoacetophenones

Indole skeletons were constructed from 2-(N-aryl-N-methylamino) acetophenones by the sequential actions of sunlight and a rhodium catalyst. This method presents an example of the direct use of sunlight in organic synthesis.

A NEW SYNTHESIS OF 3-SUBSTITUTED INDOLINES AND INDOLES

3-Phenyl- and 3-alkyl-3-hydroxyindolines were synthesized by intramolecular Barbier reaction of phenyl and alkyl N-(2-iodophenyl)-N-methylaminomethyl ketones with n-BuLi, which were easily prepared from N-methyl-2-iodoaniline and bromomethyl ketones.The treatment of the indolines with acid gave the corresponding indoles in quantitative yields.