173065-18-4

Basic information

• Product Name: Carbamic acid, (1-methylene-2-propynyl)-, 1,1-dimethylethyl ester (9CI)
• Synonyms: Carbamic acid, (1-methylene-2-propynyl)-, 1,1-dimethylethyl ester (9CI)
• CAS NO: 173065-18-4
• Molecular Formula: C₉H₁₃NO₂
• Molecular Weight: 167.20502
• Product Categories: N-BOC
• Mol File: 173065-18-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Carbamic acid, (1-methylene-2-propynyl)-, 1,1-dimethylethyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, (1-methylene-2-propynyl)-, 1,1-dimethylethyl ester (9CI)(173065-18-4)
• EPA Substance Registry System: Carbamic acid, (1-methylene-2-propynyl)-, 1,1-dimethylethyl ester (9CI)(173065-18-4)

Safety Data

• Hazardous Substances Data: 173065-18-4(Hazardous Substances Data)

Upstream product

• 130418-98-3 (S)-tert-butyl 4-(2,2-dibromovinyl)-2,2-dimethyloxazolidine-3-carboxylate 
• 95715-87-0 (R)-3-tert-butoxycarbonyl-4-formyl-2,2-dimethyloxazolidine 
• 102308-32-7 (4S)-4-formyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 173065-17-3 (R)-(-)-2,2-dimethyl-3-tert-butoxycarbonyl-4-(β,β-dibromovinyl)oxazolidine 
• 162107-48-4 tert-butyl (R)-4-ethynyl-2,2-dimethyloxazolidine-3-carboxylate 

Downstream Products

• 289721-26-2 tert-butyl 3-phenyl-4-(phenylethynyl)phenylcarbamate 

Relevant articles and documents

Palladium-catalyzed cross-benzannulation of aminoenynes with diynes. Highly regioselective synthesis of polysubstituted anilines

Polysubstituted anilines were prepared by the palladium-catalyzed cross- benzannulation of conjugated aminoenynes 1-4 with diynes 8. The reaction proceeded in a highly regioselective manner under mild conditions, and the anilines were obtained as single regioisomers. Our method complements the well-known precedures for the preparation of polysubstituted anilines which are widely used in organic synthesis.

Synthetic Elaboration of the Side Chain of (R)-2,2-Dimethyl-3-(tert-butoxycarbonyl)-4-ethynyloxazolidine: A New Regio- And Stereoselective Strategy to δ-Functionalized β-Amino Alcohols

An investigation of the reactivity of ethynyloxazolidine 2 is presented. Functionalization at the acetylenic position has been found to occur very easily using the mild Sonogashira conditions. Addition of tributyltin cuprate 1 provided the corresponding stannylated (E)-ethenyloxazolidine 3, a new chiral building block which has been reacted with electrophiles under Pd catalysis. The reaction sequence occurred without racemization and showed an easy and mild procedure for the regio- and stereoselective synthesis of unsaturated amino alcohols.