173171-93-2

Upstream product

• 80012-14-2 (E)-4-amino-pent-3-en-2-one 
• 104-88-1 4-chlorobenzaldehyde 
• 626-34-6 ethyl 3-aminobut-2-enoate 
• 123-54-6 acetylacetone 
• 60-35-5 acetamide 
• 506-87-6 ammonium carbonate 
• 105-45-3 acetoacetic acid methyl ester 

Relevant academic research and scientific papers

A novel TMSI-mediated synthesis of Hantzsch 1,4-dihydropyridines at ambient temperature

The synthesis of various substituted Hantzsch 1,4-dihydropyridines has been achieved using the classical Hantzsch procedure and modified Hantzsch conditions for the first time at room temperature in the presence of iodotrimethylsilane (TMSI) generated in situ in CH3CN, in excellent yields.

Synthesis of 1,4-dihydropyridines under solvent free conditions and investigation of their photo physical properties

Synthesis of five 4-aryl substituted 1,4-dihydropyridines was developed following condensation of multi component reaction strategy using yttrium triflate as a catalyst. The absorption and fluorescence properties of structurally related 4-aryl 1,4-dihydropyridines in different solvents of varied polarities was investigated. The absorption maxima of these compounds follow no order of solvent polarity and nature of substitution. The spectral characteristics are solvent and compound specific. Fluorophores with electron withdrawing group have larger fluorescence quantum yields and greater solvatochromism than the compounds with electron donating groups. Protic solvents yielded higher fluorescence quantum efficiency. The chemical shift of the proton attached to C-4 and the carbonyl stretching frequency of bis acetyl groups at 3 and 5-positions exhibited a linear relationship with Hammett's para substituent constants while no such relationship exists between the latter and electronic absorption maxima, fluorescence emission maxima, fluorescence quantum efficiency and Stokes shift.

Synthesis, bioinformatics and biological evaluation of novel pyridine based on 8-hydroxyquinoline derivatives as antibacterial agents: DFT, molecular docking and ADME/T studies

The present study aims to first explore the relationship between the chemical structure of the organic compounds (pyridine based on 8-hydroxyquinoline) and the antibacterial activities, as well as the impact of substituent effects on their antibacterial properties. These compounds were synthesized by efficient methods, and their structures confirmed by the spectral methods (IR, 1H NMR, 13C NMR and elemental analysis). The antibacterial activities of synthesized the compounds were checked with five Gram-positive and Gram-negative strains such as Enterobacter cloacae (ATCC29893),Escherichia coli (ATCC35218), Klebsiella pneumoniae (ATCC13883), Staphylococcus aureus (ATCC29213) and Acinetobacter baumannii (ATCC19606). The results of the antibacterial activities of four synthesized compounds were compared with three standard antibiotics [Penicillin G, Erythromycin and Norfloxacin (quinoline type)]. The minimum inhibitory concentrations (MICs) of active compounds were calculated and discussed. The chemical and biological activities of hydroxyquinoline derivatives were compared with theoretical methods. The chemical activities of hydroxyquinoline derivatives were contrasted with the important quantum chemical parameters using the HF/6–31++g (d, p) basis sets. Besides, biological activities of hydroxyquinoline derivatives against cancer proteins that are respectively protein of the BRCT repeat region of breast cancer that is ID: 1JNX, crystal structure of liver cancer protein that is ID: 3WZE, and crystal structure of lung cancer protein that is ID: 5ZMA, were compared. ADME/T (Adsorption, Distribution, Metabolism, Excretion, and Toxicity) analysis was studied for molecules with high biological activity to become efficient drugs in the future.

Ferric Sulfasalazine Sulfa Drug Complex Supported on Cobalt Ferrite Cellulose; Evaluation of Its Activity in MCRs

Abstract: The green and nano catalyst was simply prepared through the reaction of ferric sulfasalazine with nanomaterial CoFe2O4-cellulose as a magnetic biopolymer surface. This novel heterogeneous organometallic catalyst was charact

Cu-doped ZnO nanocrystalline powder as a catalyst for green and convenient multi-component synthesis of 1,4-dihydropyridine

Abstract A simple, efficient, and convenient one-step method for synthesis of Hantzsch 1,4-dihydropyridine, using Cu-doped ZnO nanocrystalline powder as a catalyst is reported. The method offers several advantages including excellent yields, green solvent, easy work-up, simplicity in operation and catalyst reusability.

Synthesis and in vitro antimicrobial activity of novel series of 3,5-diacetylpyridine compounds

Bis diacetylpyridine derivative (1) was prepared and reacted with different halo-compounds, namely: epichlorohydrine and dichloroethyl ethyl ether to give 2a,b, respectively, and reacted with morpholine and piperidine to afford Mannich products 3a,b, successively. Compound 4 was synthesized by reaction of 1 with potassium thiocyanate. Reaction of 4 with 4-chlorobenzaldehyde, glucose and phthalic or maleic anhydrides produced 5, 6 and 7a,b. Compound 1 reacted with 4-chlorobenzaldehyde to give bisanylmethylene derivative 8. Also some new compounds 9-11 were prepared from the reaction of compound 8 with nucleophiles, namely: hydrazine hydrate, thiosemicarbazide and hydroxylamine via Michael condensation reaction. On the other hand, compound 8 was reacted with cyclohexanone and cyclopentanone to give 12a,b. The structures of newly synthesized products have been deduced on the basis of elemental analysis and spectral data. Some synthesized compounds were screened for their antimicrobial evaluation. Among the assayed compounds, derivatives 3b and 12a showed the highest antimicrobial activities.

Synthesis and 3D-QSAR study of 1,4-dihydropyridine derivatives as MDR cancer reverters

A series of symmetrical and unsymmetrical 1,4-dihydropyridines were synthesized by a rapid, single pot microwave irradiation (MWI) based protocol along with conventional approach and characterized by NMR, IR and mass spectroscopic techniques. The compound

Triton-X-100 catalyzed synthesis of 1,4-dihydropyridines and their aromatization to pyridines and a new one pot synthesis of pyridines using visible light in aqueous media

A realistic and convenient synthetic method has been developed for the facile synthesis of 1,4-dihydropyridine derivatives in the presence of the non-ionic surfactant Triton X-100, in an aqueous medium at room temperature. A greener method to synthesize pyridine derivatives has also been developed by the oxidation of 1,4-dihydropyridine derivatives with almost 100% yields and also in a one pot synthesis, employing an aldehyde, ethyl acetoacetate and ammonium acetate in an aqueous micellar medium by irradiation with potassium persulphate in the presence of visible light. The one pot protocol offered excellent yields of the targeted product in a very short period of time at room temperature and the non-ionic surfactant catalyst can be recovered very easily. We also observed that during the reaction there was the formation of micelles, or micelle-like colloidal aggregates, from the non-ionic surfactant and the reaction mixture in water, measured by dynamic light scattering and visualized through an optical microscope. The process is advantageous as ammonia is generated from an ammonium salt under absolutely neutral conditions and the product purification follows a group assistant purification chemistry process (GAP).

Light induced synthesis of symmetrical and unsymmetrical dihydropyridines in ethyl lactate-water under tunable conditions

A highly efficient environment-friendly one-pot green methodology has been developed for the synthesis of symmetrical and unsymmetrical 1,4-dihydropyridines and polyhydroquinolines following the multicomponent Hantzsch synthesis under visible light irradiation in ethyl-l-lactate-water solution at room temperature. The present methodology offers several advantages such as simple procedure, greener condition, excellent yields and short reaction time sans any catalyst, support or promoter. The developed protocol has been materialized with the involvement of a household compact tungsten lamp as the visible light source, and the manifested high selectivity of the reaction performed in ethyl lactate-water solvent mixture under tunable conditions. The Ca2+ channel blocker nitrendipine and nemadipine B were also successfully synthesized applying the developed methodology in high yields.

Candida antarctica lipase B-catalyzed the unprecedented three-component Hantzsch-type reaction of aldehyde with acetamide and 1,3-dicarbonyl compounds in non-aqueous solvent

A direct approach to 1,4-dihydropyridines by lipase-catalyzed unprecedented three-component Hantzschtype reaction of aldehyde with 1,3-dicarbonyl compounds and acetamide in non-aqueous solvent has been developed. Some control experiments have been perform