173204-31-4

Basic information

• Product Name: 5'-O-dimethoxytritylthymidin-3'-yl trimethylsilyl H-phosphonothioate
• CAS NO: 173204-31-4
• Molecular Weight: 696.833
• Mol File: 173204-31-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5'-O-dimethoxytritylthymidin-3'-yl trimethylsilyl H-phosphonothioate(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-dimethoxytritylthymidin-3'-yl trimethylsilyl H-phosphonothioate(173204-31-4)
• EPA Substance Registry System: 5'-O-dimethoxytritylthymidin-3'-yl trimethylsilyl H-phosphonothioate(173204-31-4)

Safety Data

• Hazardous Substances Data: 173204-31-4(Hazardous Substances Data)

Upstream product

• 135704-44-8 C₃₆H₄₁N₂O₁₀P 
• 135704-45-9 C₃₉H₄₉N₂O₁₀PSi 
• 3385-94-2 hexamethyldisilathiane 
• 3868-27-7 triethylammonium 5'-O-dimethoxytritylthymidine 3'-H-phosphonate 
• 75-77-4 chloro-trimethyl-silane 
• 126999-87-9 O-[5'-O-(4,4'-dimethoxytrityl)thymidine-3'-yl] H-thiophosphonate triethylamine salt 

Downstream Products

• 182245-84-7 C₃₆H₃₆N₃O₈PS 

Relevant articles and documents

Efficient Method for the Preparation of Nucleoside Phosphorofluoridates and Nucleoside Phosphorofluoridothioates

Dinucleoside H-phosphonates and nucleoside H-phosphonothioates can be efficiently transformed to the fluorophosphate and fluorothiophosphate diester derivatives via iodine promoted oxidation in the presence of fluoride anions.An analogous oxidation of the

Nucleoside H-phosphonates. 15. Preparation of nucleoside H-phosphonothioate monoesters from the corresponding nucleoside H-phosphonates

A convenient method for the preparation of nucleoside 3'-H-phosphonothioate monoesters from suitably protected nucleoside 3'-H-phosphonates has been developed. It consists of activation of nucleoside H-phosphonates with pivaloyl chloride in the presence of a limited amount of a base followed by treatment with 1,1,1,3,3,3-hexamethyldisilathiane (HMDST).