135704-45-9Relevant articles and documents
Nucleoside H-phosphonates. 15. Preparation of nucleoside H-phosphonothioate monoesters from the corresponding nucleoside H-phosphonates
Zain,Stromberg,Stawinski
, p. 8241 - 8244 (1995)
A convenient method for the preparation of nucleoside 3'-H-phosphonothioate monoesters from suitably protected nucleoside 3'-H-phosphonates has been developed. It consists of activation of nucleoside H-phosphonates with pivaloyl chloride in the presence of a limited amount of a base followed by treatment with 1,1,1,3,3,3-hexamethyldisilathiane (HMDST).