135704-45-9

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 135704-44-8 C₃₆H₄₁N₂O₁₀P 
• 3868-27-7 triethylammonium 5'-O-dimethoxytritylthymidine 3'-H-phosphonate 
• 3282-30-2 pivaloyl chloride 

Downstream Products

• 173204-31-4 5'-O-dimethoxytritylthymidin-3'-yl trimethylsilyl H-phosphonothioate 

Relevant academic research and scientific papers

Nucleoside H-phosphonates. 15. Preparation of nucleoside H-phosphonothioate monoesters from the corresponding nucleoside H-phosphonates

A convenient method for the preparation of nucleoside 3'-H-phosphonothioate monoesters from suitably protected nucleoside 3'-H-phosphonates has been developed. It consists of activation of nucleoside H-phosphonates with pivaloyl chloride in the presence of a limited amount of a base followed by treatment with 1,1,1,3,3,3-hexamethyldisilathiane (HMDST).

Conversion of nucleoside H-phosphonate monoesters to the corresponding H- phosphonothioates. 31P NMR studies

31P NMR Studies on the conversion of nucleoside H-phosphonate monoesters into the corresponding H-phosphonothioates revealed that the key intermediate, the nucleoside trimethylsilyl pivaloyl phosphite 3, may undergo under the reaction condition