17321-47-0Relevant articles and documents
Spermine production process
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Paragraph 0016-0027, (2021/02/10)
The invention provides an environment-friendly spermine production process which comprises the following steps: mixing O, O-dimethylthiophosphoryl chloride with a solvent to form a uniform solution, introducing ammonia gas to react for 1-10 hours at the reaction temperature of 5-30 DEG C, and when the content of O, O-dimethylthiophosphoryl chloride in a reaction solution is analyzed to be less than 0.1% by sampling, filtering out ammonium chloride solids from the reaction solution to obtain a filtrate, namely the O, O-dimethyl thiophosphoric amide solution which can be directly used for methamidophos production. The process solves the problem of difficult treatment of wastewater in the ammonia water amination method in the prior art; according to the production process method, adopted production equipment is simple, the process flow is greatly simplified, energy consumption and production cost can be reduced, the produced by-product ammonium chloride can be sold, and the production process is environmentally friendly and economical.
Preparation method of O, O '-dimethyl thiophosphamide
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Paragraph 0023; 0025-0034, (2020/10/14)
The invention discloses a preparation method of O, O '-dimethyl thiophosphoric amide. The method comprises the following steps: adding water and O, O '-dimethyl thiophosphoryl chloride into a reactioncontainer, stirring, introducing liquid ammonia at a set temperature to enable the mass ratio of the water in the reaction container to the introduced liquid ammonia to be 1: (0.30-0.35) for ammoniation reaction, and stopping introducing the liquid ammonia when the pH value of reaction liquid reaches 8-9; after the reaction is finished, carrying out liquid-solid separation, separating out a water-phase liquid, an organic-phase liquid and a white ammonium chloride solid, and introducing the separated water-phase liquid into a reaction container for cyclic utilization; and distilling the organic phase liquid to recover the solvent, thereby obtaining O, O '-dimethyl thiophosphoric amide. According to the method, the ammonia ratio of a reaction system is increased, the speed is high, the reaction is complete, no wastewater is discharged, the yield is high and the quality is good.
Synthesis, spectroscopic characterization and structure-activity relationship of some phosphoramidothioate pesticides
Ghadimi,Asad-Samani,Ebrahimi-Valmoozi
experimental part, p. 717 - 726 (2012/07/14)
In this work, some phosphoramidothioates (PATs) with the general formula of (CH3O)2P(S)X and (CH3O)(CH3S)P(O)X, where, X = NH2 (1 & 6), NH(CH3) (2 & 7), N(CH3)2 (3 & 8), N(Et)2 (4 & 9), (CH3CH2O)2P(S)NH(CH3) (5) and (CH3CH2O)(CH3CH2S)P(O)NH(CH 3) (10), were synthesized and characterized by 31P, 31P{1H}, 13C and 1H NMR spectroscopy. The ability of the compounds to inhibit AChE was predicted by PASS software (version 1.193). They were also experimentally evaluated by a modified Ellman's assay. The structure-activity relationship (SAR) between IC50 and some physico-chemical properties such as lipophilicity (logP), electronic and steric effects of the compounds was studied. The logP values were experimentally determined by the shake-flask (gas chromatography) method. Inhibitory potency for the compounds 1-10 was 1 (3.38 mM) > 2 (3.97 mM) > 3 (4.75 mM) > 4 (6.00 mM) > 5 (5.51 mM) > 6 (0.07 mM) > 7 (0.23 mM) > 8 (0.39 mM) > and 9 (0.55 mM) > 10 (0.51 mM), respectively. IC50 and logP parameters of the P=O moiety were more than the P=S moiety in PAT analogues.