173259-61-5Relevant academic research and scientific papers
Tripeptide aldehyde inhibitors of human rhinovirus 3C protease: Design, synthesis, biological evaluation, and cocrystal structure solution of P1 glutamine isosteric replacements
Webber, Stephen E.,Okano, Koji,Little, Thomas L.,Reich, Siegfried H.,Xin, Yue,Fuhrman, Sheila A.,Matthews, David A.,Love, Robert A.,Hendrickson, Thomas F.,Patick, Amy K.,Meador III, James W.,Ferre, Rose Ann,Brown, Edward L.,Ford, Clifford E.,Binford, Susan L.,Worland, Stephen T.
, p. 2786 - 2805 (2007/10/03)
The investigation of tripeptide aldehydes as reversible covalent inhibitors of human rhinovirus (HRV) 3C protease (3CP) is reported. Molecular models based on the apo crystal structure of HRV-14 3CP and other trypsin- like serine proteases were constructe
Synthesis of phosphoramide analogues of sphinganine-1-phosphate
Schick, Andreas,Kolter, Thomas,Giannis, Athanassios,Sandhoff, Konrad
, p. 2945 - 2956 (2007/10/03)
Phosphoramide derivatives 13 and 15 were prepared as analogues of sphinganine-1-phosphate (4). Key steps of the synthesis are the alkylation of N-methoxy-N-methylcarboxyamide of the diaminopropanoic acid 7 and the subsequent reduction of the intermediatel
Synthesis of crystalline orthogonally N-protected (S)- or (R)-2,3-diaminopropionaldehyde from L- or D-aspartic acid
Schirlin,Altenburger
, p. 1351 - 1352 (2007/10/02)
Procedures are described for the easy preparation of crystalline orthogonally N-protected (S)- or (R)-2,3-diaminopropionaldehyde of high optical purity from L- or D-aspartic acid, respectively, and in reasonable yields.
