173282-25-2

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 173282-24-1 ethyl 3-amino-4-(2,4-difluorophenoxy)phenylpropionate 
• 16588-34-4 4-chloro-3-nitro-benzaldehyde 
• 173282-22-9 4-(2,4-difluorophenoxy)-3-nitrobenzaldehyde 
• 367-27-1 2,4-difluorophenol 

Downstream Products

• 173282-26-3 4-(2,4-difluorophenoxy)-3-methanesulfonamidophenylpropionic acid 
• 80937-31-1 flosulide 
• 1027942-72-8 4-(2,4-difluorophenoxy)-3-methanesulfonamidophenylpropionic acid chloride 

Relevant academic research and scientific papers

Improved synthesis of a selective COX-2 inhibitor, 6-(2,4-difluorophenoxy)-5-methane-sulfonamidoindan-1-one (flosulide)

An improved synthesis of Flosulide (1), a selective COX-2 inhibitor, from the cheap and commercially available 4-chloro-3-nitrobenzaldehyde (2) by using an intramolecular Friedel-Crafts reaction of 4-(2,4-difluorophenoxy)-3-methanesulfonamidophenylpropionic acid (7) as the key step is reported.