80937-31-1

Usage

InChI:InChI=1/C16H13F2NO4S/c1-24(21,22)19-13-6-9-2-4-14(20)11(9)8-16(13)23-15-5-3-10(17)7-12(15)18/h3,5-8,19H,2,4H2,1H3

Upstream product

• 367-27-1 2,4-difluorophenol 
• 81614-79-1 6-(2,4-difluorophenoxy)-5-indanylamine 
• 82505-51-9 5-acetylamino-6-(2,4-difluorophenoxy)-1-indanone 
• 82505-48-4 6-(2,4-Difluoro-phenoxy)-5-nitro-indan-1-one 
• 16588-34-4 4-chloro-3-nitro-benzaldehyde 
• 173282-25-2 ethyl 4-(2,4-difluorophenoxy)-3-methanesulfonamidophenylpropionate 
• 173282-26-3 4-(2,4-difluorophenoxy)-3-methanesulfonamidophenylpropionic acid 
• 173282-24-1 ethyl 3-amino-4-(2,4-difluorophenoxy)phenylpropionate 
• 173282-22-9 4-(2,4-difluorophenoxy)-3-nitrobenzaldehyde 
• 1027942-72-8 4-(2,4-difluorophenoxy)-3-methanesulfonamidophenylpropionic acid chloride 
• 124-63-0 methanesulfonyl chloride 
• 82505-55-3 5-amino-6-(2,4-difluorophenoxy)-1-indanone 

Downstream Products

• 88040-98-6 N-[6-(2,4-difluorophenoxy)-1-methylamino-5-indanyl]methanesulfonamide, hydrochloride 
• 83498-50-4 N-[6-(2,4-difluorophenoxy)-1-hydroxy-5-indanyl]methanesulfonamide 

Relevant academic research and scientific papers

Method for the treatment and prevention of cachexia

Cachexia, including anorexia and other forms of weight loss, is a frequent complication of acute and chronic infections, and result from induction of cytokines, prostaglandins, and other inflammatory mediators that are critical for pathogen elimination. The present invention includes methods for the treatment or prevention of cachexic conditions while maintaining the production of factors essential for infection control through the administration of an effective amount of a cyclooxygenase-2 selective inhibiting compound.

Antiangiogenic combination therapy for the treatment of cancer

The present invention provides combinations of a DNA topoisomerase I inhibiting agent and a selective COX-2 inhibiting agent for preventing, treating, and/or reducing the risk of developing a neoplasia disorder in a mammal.

Improved synthesis of a selective COX-2 inhibitor, 6-(2,4-difluorophenoxy)-5-methane-sulfonamidoindan-1-one (flosulide)

An improved synthesis of Flosulide (1), a selective COX-2 inhibitor, from the cheap and commercially available 4-chloro-3-nitrobenzaldehyde (2) by using an intramolecular Friedel-Crafts reaction of 4-(2,4-difluorophenoxy)-3-methanesulfonamidophenylpropionic acid (7) as the key step is reported.