173288-95-4

Upstream product

• 1027981-81-2 12-Benzyloxy-dodecanoic acid methyl ester 
• 505-95-3 12-hydroxydodecanoic acid 
• 100-52-7 benzaldehyde 
• 71655-36-2 methyl 12-hydroxydodecanoate 
• 95301-49-8 benzyl-(12-bromododecyl)-ether 
• 124-38-9 carbon dioxide 
• 144878-51-3 11-bromoundecan-1-yl benzyl ether 

Downstream Products

• 830322-76-4 12-benzyloxydodecanoic acid 2-(12-benzyloxydodecanoyloxy)-3-dimethylaminopropyl ester 
• 1037297-73-6 C₈₇H₁₁₇NO₁₂ 

Relevant academic research and scientific papers

Ni-catalyzed carboxylation of unactivated primary alkyl bromides and sulfonates with CO2

A Ni-catalyzed carboxylation of unactivated primary alkyl bromides and sulfonates with CO2 at atmospheric pressure is described. The method is characterized by its mild conditions and remarkably wide scope without the need for air- or moisture-sensitive reagents, which make it a user-friendly and operationally simple protocol en route to carboxylic acids.

Functional synthetic molecules and macromolecules for gene delivery

The present invention describes a synthetic non-viral vector composition for gene therapy and the use of such compositions for in vitro, ex vivo and/or in vivo transfer of genetic material. The invention proposes a pharmaceutical composition containing 1) a non-cationic amphiphilic molecule or macromolecule and its use for delivery of nucleic acids or 2) a cationic amphiphilic molecule or macromolecule that transforms from a cationic entity to an anionic, neutral, or zwitterionic entity by a chemical, photochemical, or biological reaction and its use for delivery of nucleic acids. Moreover this invention describes the use of these non-viral vector compositions in conjunction with a surface to mediate the delivery of nucleic acids. An additional embodiment is the formation of a hydrogel with these compositions and the use of this hydrogel for the delivery of genetic material. A further embodiment of this invention is the use of a change in ionic strength for the delivery of genetic material.

Bismuth trichloride catalyzed efficient reductive etherification of carbonyl compounds with alcohols: A novel method for preparation of symmetrical and unsymmetrical ethers

The reductive homocoupling of a carbonyl compound and heterocoupling of a carbonyl compound with a non-protected alcohol were both effected smoothly at room temperature with triethylsilane in the presence of a catalytic amount of bismuth trichloride to afford the corresponding ethers in good yields.

Structure-antitumor activity relationship of semi-synthetic spicamycin derivatives

New derivatives of spicamycin modified at the fatty acid moieties of the molecule were synthesized and their structure-activity relationships were examined. The antitumor activity was greatly influenced by modification of the fatty acid moieties to tetradecadienoyl or dodecadienoyl analogues exhibiting better antitumor activity against COL-1 human colon cancer xenograft than SPM VIII.