17331-20-3

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 17331-12-3 N⁶-(dimethylamino-methylene)-2'-deoxy-adenosine 
• 958-09-8 2'-deoxy-D-adenosine 

Downstream Products

• 154656-78-7 N⁶-dimethylformamidine-2'-deoxyadenosine-3'-diisopropylaminocyanoethyl phosphoramidite 
• 145432-04-8 1,8-diazabicyclo[5.4.0]undec-7-enium 5'-O-(4,4'-dimethoxytrityl)deoxyadenosin-3'-yl phosphonate 
• 145432-00-4 C₃₄H₃₇N₆O₇P*C₉H₁₆N₂ 
• 1089723-14-7 C₄₅H₄₈N₇O₆P 
• 1133388-22-3 C₄₆H₅₀N₇O₆P 
• 1233510-51-4 3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-6-N-[(dimethylamino)methylene]-2'-deoxyadenosine 
• 51549-31-6 3'-O-(tert-butyldimethylsilyl)-2'-deoxyadenosine 
• 1082489-79-9 3'-O-(tert-butyldimethylsilyl)-6-N-[(dimethylamino)methylene]-5'-O-[(4-methoxytrityl)sulfenyl]-2'-deoxyadenosine 
• 1082489-87-9 6-N-[(dimethylamino)methylene]-5'-O-[(4-methoxytrityl)sulfenyl]-2'-deoxyadenosine 3'-(2-cyanoethyl-N,N-diisopropylphosphoramidite) 
• 1233510-66-1 6-N-[(dimethylamino)methylene]-5'-O-[(4-methoxytrityl)sulfenyl]-2'-deoxyadenosine 
• 1233510-54-7 3'-O-(tert-butyldimethylsilyl)-5'-O-[(4-methoxytrityl)sulfenyl]-2'-deoxyadenosine 

Relevant academic research and scientific papers

H-phosphonate DNA synthesis without amino protection

DNA synthesis by the H-phosphonate method does not require the use of amino protecting groups. The cytosine amino group, and the guanine O6/N1 positions, do react with the condensing agent to some extent, but these derivatives are cleaved under the standa

FAST OLIGONUCLEOTIDE DEPROTECTION. PHOSPHORAMIDITE CHEMISTRY FOR DNA SYNTHESIS

A new set of base protecting groups for cyanoethylphosphoramidite nucleosides has been developed which decreases the post-synthesis time requirements.The traditional purine amide protecting groups, which require 8 - 16 hours at 55 deg C for deprotection in ammonia, have been replaced with the dimethylformamidine group.Oligonucleotides made with the new reagents require only 1 hour at 55 deg C or 8 hours at room temperature for complete deprotection.Dialkylformamidine phosphoramidites exhibit enhanced resistance to depurination compared to the traditional, or even the phenoxyacetyl, phosphoramidites.