50622-95-2

Upstream product

• 1138-80-3 N-(Benzyloxycarbonyl)glycine 
• 1145-81-9 ethyl 2-(benzyloxycarbonylamino)ethanoate 
• 7647-01-0 hydrogenchloride 
• 5680-83-1 N-(benzyloxycarbonyl)glycine hydrazide 
• 64-19-7 acetic acid 

Downstream Products

• 112819-93-9 N-(N-benzyloxycarbonyl-glycyl)-N'-[N-(N-benzyloxycarbonyl-glycyl)-alanyl]-hydrazine 
• 108849-83-8 benzyloxycarbonyl-Gly-Ser-OMe 
• 108849-83-8 N-(N-benzyloxycarbonyl-glycyl)-L-serine methyl ester 
• 17331-93-0 N-benzyloxycarbonylglycyl-L-leucine methyl ester 
• 3017-50-3 N,N'-bis-(N-benzyloxycarbonyl-glycyl)-hydrazine 
• 3916-39-0 benzyloxycarbonylglycylglutamic acid 
• 13443-59-9 N-benzyloxycarbonylglycylglycylglycyne methyl ester 
• 79590-41-3 N⁶-benzyloxycarbonyl-N²-(N-benzyloxycarbonyl-glycyl)-L-lysine methyl ester 
• 2489-13-6 GH 
• 17682-11-0 N^α-(N-benzyloxycarbonyl-glycyl)-histidine hydrazide 
• 896436-37-6 -benzylester 
• 888937-70-0 -benzylester 
• 112037-37-3 Z-Gly-NCO 
• 93788-19-3 bis(N-benzyloxycarbonylglycyl)diaza-18-crown-6 

Relevant academic research and scientific papers

High-Fidelity End-Functionalization of Poly(ethylene glycol) Using Stable and Potent Carbamate Linkages

Commercial PEG-amine is of unreliable quality, and conventional PEG functionalization relies on esterification and etherification steps, suffering from incomplete conversion, harsh reaction conditions, and functional-group incompatibility. To solve these challenges, we propose an efficient strategy for PEG functionalization with carbamate linkages. By fine-tuning terminal amine basicity, stable and high-fidelity PEG-amine with carbamate linkage was obtained, as seen from the clean MALDI-TOF MS pattern. The carbamate strategy was further applied to the synthesis of high-fidelity multi-functionalized PEG with varying reactive groups. Compared to with an ester linkage, amphiphilic PEG-PS block copolymers bearing carbamate junction linkage exhibits preferential self-assembly tendency into vesicles. Moreover, nanoparticles of the latter demonstrate higher drug loading efficiency, encapsulation stability against enzymatic hydrolysis, and improved in vivo retention at the tumor region.

3,3-dichloro-1,2-diphenylcyclopropene (CPICL)-mediated synthesis of n α-protected amino acid azides and α-ureidopeptides

Rapid synthesis of acid azides via in situ generation of acid chlorides using CPICl as chlorinating agent from the corresponding Nα- protected amino acids is described. Also the conversion of acid azides into ureidopeptides through the Curtius rearrangement under ultrasonication is delineated. The mildness of the protocol renders the acid-sensitive substrates to afford the corresponding amino acid azides and ureidopeptides in good yields. Diphenylcyclopropenone has also been recovered from the reaction mixture and reused. Georg Thieme Verlag Stuttgart New York.

MACROHETEROCYCLES. XVII. SYNTHESIS AND ENANTIOSELECTIVE CHARACTERISTICS OF CHIRAL N,N'-DIACYLDIAZA-18-CROWN-ETHERS

N,N'-Diacyldiaza-18-crown-6 ethers were obtained by the acylation of diaza-18-crown-6 with amino acids.The enantioselectivity coefficients were determined for the chiral compound in relation to the L and D isomers of valine.The obtained compounds represent a promising class of enantioselective complexones.

Amino Acids and Peptides. VI. Curtius Rearrangement of Acyl Amino Acid and Peptide Azides and Reactivity of the Isocyanates

Studies on the rate of Curtius rearrangement of acyl amino acid and peptide azides were carried out by means of IR (infrared) spectrophotometry at 25 deg.It was found that Z-Gly-N3 and Z-Pro-N3 were more stable than the other acyl amino acid azides.The re