173313-23-0Relevant articles and documents
Asymmetric synthesis of 4-phenyl-1,5-diazacyclooctan-2-one using optically active vinyl sulfoxides
Itoh,Matsuyama,Yoshida,Kamigata,Iyoda
, p. 3121 - 3130 (1995)
Both enantiomers of (S)- and (R)-4-phenyl-1,5-diazacyclooctan-2-ones (7) were synthesized stereoselectively with good optical purity by the asymmetric conjugate addition of pyrazolidine to optically active vinyl sulfoxides, t-butyl (E)-2-[(R)- and (S)-p-tolylsulfinyl]cinnamates, respectively. Starting from 7, a synthesis of optically active homaline was achieved.
One step synthesis of optically active diazabicyclo-[3.3.0] octanones or diazabicyclo [4.3.0] nonanones by asymmetric conjugate addition of cyclic hydrazine
Seki, Chigusa,Hirama, Masafumi,Sato, Takeshi,Takeda, Saya,Kohari, Yoshihito,Ishigaki, Kazuhiro,Ohuchi, Masafumi,Yokoi, Kiyoshi,Nakano, Hiroto,Uwai, Koji,Takano, Nobuhiro,Umemura, Kazuyuki,Matsuyama, Haruo
, p. 1045 - 1052 (2012/07/28)
Asymmetric conjugate addition-cyclization of lithium amide of 6-membered hydrazine 4, piperidazine, (or 5-membered hydrazine 6, pyrazolidine) to N-(E)-cinnamoyl-(1S)-2,10-camphorsultam (1S)-3 afforded β-amino acid derivative (S)-1 {or (S)-2} for the synthesis of polyamine alkaloids in good yield with good stereoselectivity (up to 86% ee).