173339-02-1Relevant articles and documents
Synthesis and anti-tumor activity of new steroidal nuclear analogues of aragusterol A
Mitome, Hidemichi,Shinohara, Masakazu,Miyaoka, Hiroaki,Yamada, Yasuji
, p. 640 - 645 (2007/10/03)
3α,7α-Dihydroxy-5-epiaragusterol A (3) was synthesized from bile acid (cholic acid) as a new steroidal nuclear analogue of antitumor marine steroid aragusterol A. 7α-Hydroxyaragusterol A (4) was also derived from xestokerol B. The in vitro anti-proliferat
Cyclization into Hydrindanones Using Samarium Diiodide
Sono, Masakazu,Nakashiba, Yasuyo,Nakashima, Katsuyuki,Tori, Motoo
, p. 3099 - 3106 (2007/10/03)
Samarium(II) iodide has been employed to promote vinylogous pinacol coupling reaction of aldehyde onto α,β-unsaturated ketones. The diastereoselectivity of 6-endo products was changed by addition of a proton source and/or HMPA and by the reaction temperature. The cyclization reactions described herein provide a general approach to the syntheses of 3,3-dimethylhydrindanes with a cis-relationship between the OH at C-4 and the proton at C-3a with good diastereoselectivity and under mild reaction conditions.