281661-49-2

Upstream product

• 281661-44-7 1-(tert-butyl-dimethyl-silanyloxy)-6-[3-(tert-butyl-diphenyl-silanyloxy)-1-methyl-propyl]-2,2-dimethyl-oct-7-en-4-ol 
• 281661-46-9 6-[3-(tert-butyl-diphenyl-silanyloxy)-1-methyl-propyl]-2,2-dimethyl-oct-7-ene-1,4-diol 
• 281661-42-5 3-[3-(tert-butyl-diphenyl-silanyloxy)-1-methyl-propyl]-pent-4-enal 
• 7540-51-4 (S)-3,7-dimethyl-6-octen-1-ol 
• 281661-38-9 3-[3-(tert-butyl-diphenyl-silanyloxy)-1-methyl-propyl]-pent-4-enoic acid methyl ester 
• 281661-52-7 3-[3-(tert-butyl-diphenyl-silanyloxy)-1-methyl-propyl]-pent-4-en-1-ol 
• 281661-33-4 (E)-(R)-6-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-hex-2-enal 
• 281661-48-1 6-[3-(tert-butyl-diphenyl-silanyloxy)-1-methyl-propyl]-2,2-dimethyl-4-oxo-oct-7-enal 
• 173339-02-1 (E)-(R)-6-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-hex-2-enoic acid methyl ester 
• 281661-31-2 (S)-6-(tert-butyldiphenylsilyloxy)-4-methylhexanal 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Relevant academic research and scientific papers

Cyclization into Hydrindanones Using Samarium Diiodide

Samarium(II) iodide has been employed to promote vinylogous pinacol coupling reaction of aldehyde onto α,β-unsaturated ketones. The diastereoselectivity of 6-endo products was changed by addition of a proton source and/or HMPA and by the reaction temperature. The cyclization reactions described herein provide a general approach to the syntheses of 3,3-dimethylhydrindanes with a cis-relationship between the OH at C-4 and the proton at C-3a with good diastereoselectivity and under mild reaction conditions.