173417-10-2Relevant academic research and scientific papers
Photochemical Hydrolysis of o-Acetylphenylacetonitriles
Lu, Qingyi,Bovonsombat, Pakorn,Agosta, William C.
, p. 8941 - 8944 (1995)
Irradiation of 1 and its methyl derivative 10a (λ>280 nm) in methanol leads to photohydrolysis of the nitrile group and formation of the related ketal amides 3 and 11a, respectively.Similar treatment of the dimethyl derivative 10b and of the parent nitrile 13 fails to yield corresponding products of hydrolysis.A mechanism is proposed for these novel hydrolyses.
Novel photochemical hydrolysis of o-acetylphenylacetonitriles to amides
Lu, Qingyi,Bovonsombat, Pakorn,Agosta, William C.
, p. 3729 - 3732 (2007/10/03)
Irradiation of o-acetylphenylacetonitriles 1a,b in methanol (λ >280 nm) leads to essentially quantitative photohydrolysis with formation of the corresponding ketal amides 3a,b. The mechanism proposed for this novel reaction is supported by the qualitatively different photochemical behavior of 1c and by a labeling experiment with 1a-L that confirms transfer of the carbonyl oxygen atom of 1a to the amide oxygen atom of 3a.
