17344-59-1Relevant articles and documents
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Blomquist,Holley
, p. 36,38 (1948)
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Stereoselective access to Z and e macrocycles by ruthenium-catalyzed Z-selective ring-closing metathesis and ethenolysis
Marx, Vanessa M.,Herbert, Myles B.,Keitz, Benjamin K.,Grubbs, Robert H.
supporting information, p. 94 - 97 (2013/04/10)
The first report of Z-selective macrocyclizations using a ruthenium-based metathesis catalyst is described. The selectivity for Z macrocycles is consistently high for a diverse set of substrates with a variety of functional groups and ring sizes. The same catalyst was also employed for the Z-selective ethenolysis of a mixture of E and Z macrocycles, providing the pure E isomer. Notably, an ethylene pressure of only 1 atm was required. These methodologies were successfully applied to the construction of several olfactory macrocycles as well as the formal total synthesis of the cytotoxic alkaloid motuporamine C.
