173443-43-1

Basic information

• Product Name: (4-IODO-BENZYL)-PHOSPHONIC ACID DIETHYL ESTER
• Synonyms: (4-IODO-BENZYL)-PHOSPHONIC ACID DIETHYL ESTER;Diethyl (4-Iodobenzyl)phosphonate
• CAS NO: 173443-43-1
• Molecular Formula: C₁₁H₁₆IO₃P
• Molecular Weight: 354.121171
• Product Categories: Horner-Emmons Reaction;Synthetic Organic Chemistry;Wittig & Horner-Emmons Reaction
• Mol File: 173443-43-1.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 378.3°C at 760 mmHg
• Flash Point: 182.6°C
• Appearance: /
• Density: 1.53
• Vapor Pressure: 1.38E-05mmHg at 25°C
• Refractive Index: 1.5520 to 1.5560
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (4-IODO-BENZYL)-PHOSPHONIC ACID DIETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (4-IODO-BENZYL)-PHOSPHONIC ACID DIETHYL ESTER(173443-43-1)
• EPA Substance Registry System: (4-IODO-BENZYL)-PHOSPHONIC ACID DIETHYL ESTER(173443-43-1)

Safety Data

• Hazardous Substances Data: 173443-43-1(Hazardous Substances Data)

Usage

General Description

(4-IODO-BENZYL)-PHOSPHONIC ACID DIETHYL ESTER is a chemical compound that contains elements like phosphorus, iodine, and carbon among others. As a chemical compound, it is primarily used for biochemical and pharmaceutical research, particularly in the creation of new drugs and medicines. It belongs to the category of organophosphorus compounds, which are typically used in making flame retardants, pesticides, and plasticizers. It can be hazardous to the environment and human health if not handled properly. Professional and skilled chemists who understand its properties, potential risks, and safety directives are expected to handle this substance.

InChI:InChI=1/C11H16IO3P/c1-3-14-16(13,15-4-2)9-10-5-7-11(12)8-6-10/h5-8H,3-4,9H2,1-2H3

Upstream product

• 16004-15-2 1-bromomethyl-4-iodobenzene 
• 762-04-9 phosphonic acid diethyl ester 
• 78-40-0 triethyl phosphate 
• 1067-71-6 Diethyl (2-oxopropyl)phosphonate 
• 624-38-4 para-diiodobenzene 
• 122-52-1 triethyl phosphite 

Downstream Products

• 663933-31-1 C₆H₄C₂H₂IC₆H₄CH(OCH₂CH₃)2 
• 895130-99-1 diethyl [4-(diphenylphosphanyl)benzyl]phosphonate 
• 156017-41-3 [Difluoro-(4-iodo-phenyl)-methyl]-phosphonic acid diethyl ester 
• 1027275-77-9 C₄₂H₄₀O₆P₂ 
• 1197202-15-5 (E,E)-1-styryl-4-[(3-methoxycarbonyl)-4-methoxymethoxy]styrylbenzene 
• 1197202-11-1 (E,E)-1-styryl-4-[4-(methoxymethoxy)styryl]benzene 
• 54842-60-3 1-methoxy-4-((E)-4-((E)-styryl)styryl)benzene 
• 57045-42-8 (E,E)-1-styryl-4-(4-cyanostyryl)benzene 
• 1197202-18-8 (E,E)-1-(4-methoxymethoxystyryl)-4-(4-methoxystyryl)benzene 
• 1197202-21-3 (E,E)-1-(4-methoxymethoxystyryl)-4-(4-cyanostyryl)benzene 
• 1197202-33-7 (E)-4-iodostyrylmethoxymethoxybenzene 
• 1197202-24-6 (E,E)-1-(4-methoxycarbonylstyryl)-4-(4-methoxystyryl)benzene 
• 1197202-26-8 (E,E)-1-(4-methoxycarbonylstyryl)-4-(4-cyanostyryl)benzene 
• 1075218-62-0 (E)-4-iodostyrylnitrobenzene 

Relevant articles and documents

Stimuli-responsive triphenylethylene photochromic material and synthetic method and application thereof

The invention discloses a stimuli-responsive triphenylethylene photochromic material and a synthetic method and application thereof. The stimuli-responsive triphenylethylene photochromic material is a triphenylethylene material with a stimuli-responsive f

Synthesis and evaluation of stilbene derivatives as a potential imaging agent of amyloid plaques

Fluorescence probes that can detect Aβ (β-amyloid peptide) plaque are important tools for diagnosis of Alzheimer's disease (AD), and 4-N-methylamino-4′-hydroxystilbene (SB-13) is one of the promising candidate molecules. We report here the synthesis of SB-13 derivatives that consist of various electron donating/withdrawing moieties and distinct size of N-substituents. The synthesized compounds were screened for detection of Aβ40 fibrils in vitro. Four compounds exhibited more than sixfold intensity increase, and they were further analyzed for detail bindings and Aβ plaque imaging. Among these molecules, compound 42 meets two critical requirements for imaging agent; high fluorescence responsiveness and strong binding affinity. This compound showed more than 25-fold increase with the dissociation constant of 1.13 ± 0.37 μM. In AD mouse brain tissue, 42 selectively stained Aβ plaque, more specifically peripheral regions of Aβ plaque. This finding demonstrated its potential use as brain-imaging agents for AD studies.

Synthesis and coordination properties of palladium(II) and platinum(II) complexes with phosphonated triphenylphosphine derivatives

Two triphenylphosphine derivatives, diethyl [4-(diphenylphosphanyl)benzyl]phosphonate (3a) and tetraethyl {[5-(diphenylphosphanyl)-1,3-phenylene]dimethylene}bis(phosphonate) (3b), and also the corresponding free acids 4a and 4b were prepared. These ligands were characterized by 1H, 13C and 31P NMR spectroscopy and mass spectrometry. A full set of their Pd(II) and Pt(II) complexes of the general formula [MCl2L2] and one dinuclear complex trans-[Pd2Cl4(3a)2] were synthesized and their isomerization behaviour in solution was studied. The complexes were characterized by 1H, 13C, 31P and 195Pt NMR spectroscopy, mass spectrometry and far-IR spectroscopy. The X-ray structures of all complexes with 3a or 3b have usual slightly distorted square-planar geometry on the metal ion. Salts of phosphonic acids 4a and 4b and their complexes are freely soluble in aqueous solution; therefore, they can be potentially useful in aqueous or biphasic catalysis.