173449-96-2Relevant academic research and scientific papers
Suppressive effect of arctium lappa l. leaves on retinal damage against A2E-induced ARPE-19 cells and mice
Kim, Dong Hee,Choi, Yae Rim,Shim, Jaewon,Choi, Yun-Sang,Kim, Yun Tai,Kim, Mina K.,Kim, Min Jung
, (2020)
Age-related macular degeneration (AMD) is a major cause of irreversible loss of vision with 80-90% of patients demonstrating dry type AMD. Dry AMD could possibly be prevented by polyphenol-rich medicinal foods by the inhibition of N-retinylidene-N-retinyl
Toxic effects of A2E in human ARPE-19 cells were prevented by resveratrol: a potential nutritional bioactive for age-related macular degeneration treatment
Alaimo, Agustina,Di Santo, Mariana Carolina,Domínguez Rubio, Ana Paula,Chaufan, Gabriela,García Li?ares, Guadalupe,Pérez, Oscar Edgardo
, p. 553 - 572 (2020)
Age-related macular degeneration (AMD) is a late-onset retinal disease and the leading cause of central vision loss in the elderly. Degeneration of retinal pigment epithelial cells (RPE) is a crucial contributing factor responsible for the onset and progr
Comparison of A2E cytotoxicity and phototoxicity with all-trans-retinal in human retinal pigment epithelial cells
Wielgus, Albert R.,Chignell, Colin F.,Ceger, Patricia,Roberts, Joan E.
, p. 781 - 791 (2010)
All-trans-retinal is the precursor of A2E, a fluorophore within lipofuscin, which accumulates in human retinal pigment epithelial (hRPE) cells and contributes to age-related macular degeneration. Here we have compared the in vitro dark cytotoxicity and vi
Compositional studies of human RPE lipofuscin: Mechanisms of molecular modifications
Murdaugh,Mandal,Dill,Dillon,Simon,Gaillard
, p. 90 - 95 (2011)
The accumulation of lipofuscin has previously been implicated in several retinal diseases including Best's macular dystrophy, Stargardt's disease and age-related macular degeneration (AMD). Previously one of the major fluorophores of lipofuscin was identi
Biomarkers of inflammation in Bruch's membrane of the human retina
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Page/Page column 8; 9, (2016/02/26)
A method of diagnosing a patient with age-related macular degeneration (AMD), by detecting biomarkers in the patient's Bruch's membrane, and diagnosing the patient with AMD. A method of detecting the presence of AMD in a patient, by detecting biomarkers i
Pharmaceutical composition comprising N-retinyl-N-retinylidene Ethanolamine (A2E), isoforms of A2E or derivatives thereof
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Page 10-11, (2008/06/13)
The present invention relates to a pharmaceutical composition comprising N-retinyl-N-retinylidene ethanolamine (A2E), isoforms of A2E or derivatives thereof which induce apoptosis by detaching pro-apoptotic proteins from mitochondria. Further, an antidote for said pharmaceutical composition is disclosed. The invention further relates to a use of N-retinyl-N-retinylidene ethanolamine (A2E), isoforms of A2E or derivatives for the preparation of a pharmaceutical composition and the use of phospholipids for the preparation of an antidote for said pharmaceutical composition. Moreover a method for the treatment of proliferative diseases and a method of screening for isoforms of A2E or derivatives thereof which induce apoptosis by detaching pro-apoptotic proteins from mitochondria are disclosed.
Fluorescent pigments of the retinal pigment epithelium and age-related macular degeneration
Ben-Shabat, Shimon,Parish, Craig A.,Hashimoto, Masaru,Liu, Jianghua,Nakanishi, Koji,Sparrow, Janet R.
, p. 1533 - 1540 (2007/10/03)
The major hydrophobic fluorophore of the retinal pigment epithelium (RPE) is A2E, a pyridinium bis-retinoid derived from all-trans-retinal and phosphatidyl-ethanolamine. The accumulation of fluorophores such as A2E is implicated in the pathogenesis of age-related macular degeneration (AMD), a disease associated with the deterioration of central vision and a leading cause of blindness in the elderly. Recent chemical and biological studies have provided insight into the synthesis and biosynthesis of A2E, the spectroscopic properties of this pigment, and the role of A2E and RPE cell death.
