173472-38-3Relevant articles and documents
The synthesis of di(hydroxyalkyl) substituted bicyclic guanidines
Madder, A.,Muenster, I.,Rolle, U.,Clercq, P. J. De
, p. 613 - 622 (2007/10/03)
The synthesis of the enantiomerically pure bicyclic guanidines 3a and 3b is described.The convergent strategy is based on methodology developed by Schmidtchen.The therefore required amine components 6 and 9 obtained from methionine and L-glutamic acid, respectively.
Synthesis of a Chiral Di(hydroxyalkyl) Substituted Bicyclic Guanidine
Muenster, Ingo,Rolle, Ulrike,Madder, Annemieke,Clerq, Pierre J. De
, p. 2673 - 2674 (2007/10/03)
Schmidtchen's methodology is used successfully for the synthesis of the chiral disubstituted bicyclic guanidinium salt 2.The two therefore required primary amine compounds 6 and 9 are obtained from L-methionine and L-glutamic acid, respectively.