173472-46-3

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 17342-08-4 (S)-Pyroglutaminol 
• 51693-17-5 (S)-toluene-4-sulfonic acid 5-oxo-pyrrolidin-2-ylmethyl ester 
• 72479-06-2 2-[(2S)-5-oxopyrrolidin-2-yl]acetonitrile 
• 124-41-4 sodium methylate 
• 173472-45-2 [(S)-5-Oxo-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-acetonitrile 

Downstream Products

• 173472-47-4 N-[(S)-1-(2-Amino-ethyl)-4-hydroxy-butyl]-4-methyl-benzenesulfonamide 
• 202532-13-6 N-[(S)-1-(2-{3-[(S)-3-(tert-Butyl-dimethyl-silanyloxy)-1-(2-methylsulfanyl-ethyl)-propyl]-thioureido}-ethyl)-4-(tert-butyl-diphenyl-silanyloxy)-butyl]-4-methyl-benzenesulfonamide 
• 173472-40-7 N-[(S)-4-(tert-Butyl-diphenyl-silanyloxy)-1-(2-{3-[(R)-1-(2-methylsulfanyl-ethyl)-3-triethylsilanyloxy-propyl]-thioureido}-ethyl)-butyl]-4-methyl-benzenesulfonamide 
• 173472-41-8 (2S,8S)-2-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-1-(toluene-4-sulfonyl)-8-(2-triethylsilanyloxy-ethyl)-1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine 
• 173472-38-3 N-[(S)-1-(2-Amino-ethyl)-4-(tert-butyl-diphenyl-silanyloxy)-butyl]-4-methyl-benzenesulfonamide 

Relevant academic research and scientific papers

The synthesis of di(hydroxyalkyl) substituted bicyclic guanidines

The synthesis of the enantiomerically pure bicyclic guanidines 3a and 3b is described.The convergent strategy is based on methodology developed by Schmidtchen.The therefore required amine components 6 and 9 obtained from methionine and L-glutamic acid, respectively.

Synthesis of a Chiral Di(hydroxyalkyl) Substituted Bicyclic Guanidine

Schmidtchen's methodology is used successfully for the synthesis of the chiral disubstituted bicyclic guanidinium salt 2.The two therefore required primary amine compounds 6 and 9 are obtained from L-methionine and L-glutamic acid, respectively.