1735-33-7Relevant academic research and scientific papers
Synthetic Sphingolipids with 1,2-Pyridazine Appendages Improve Antiproliferative Activity in Human Cancer Cell Lines
Bachollet, Sylvestre P. J. T.,Vece, Vito,Mccracken, Alison N.,Finicle, Brendan T.,Selwan, Elizabeth,Ben Romdhane, Nadine,Dahal, Amogha,Ramirez, Cuauhtemoc,Edinger, Aimee L.,Hanessian, Stephen
, p. 686 - 690 (2020)
A synthetic sphingolipid related to a ring-constrained hydroxymethyl pyrrolidine analog of FTY720 that was known to starve cancer cells to death was chemically modified to include a series of alkoxy-tethered 3,6-substituted 1,2-pyridazines. These derivati
Redox potential tuning of s-tetrazine by substitution of electron-withdrawing/donating groups for organic electrode materials
Kwon, Ji Eon,Lee, Kyunam,Min, Dong Joo,Park, Hyunji,Park, Soo Young
, (2021/06/12)
Herein, we tune the redox potential of 3,6-diphenyl-1,2,4,5-tetrazine (DPT) by introducing various electron-donating/withdrawing groups (methoxy, t-butyl, H, F, and trifluoromethyl) into its two peripheral benzene rings for use as electrode material in a
Catalyst-free photooxidation reaction from 1,4-dihydropyridazine to pyridazine under air
Fujii, Hideaki,Itoh, Kennosuke,Karaki, Fumika,Kiguchi, Takuto,Konishi, Kazuhide,Sato, Noriko
supporting information, (2021/09/16)
In the inverse electron-demand Diels–Alder (iEDDA) reactions between tetrazines and strained alkenes, a mixture of 1,4-dihydropyridazine isomers are formed first, and they are then oxidized to pyridazines. Although the products of these related oxidation processes converge as pyridazines, the oxidation rate is quite low with some substrates. In this study, we revealed that 1,4-dihydropyridazines formed in the iEDDA reactions were oxidized to pyridazines by simply irradiating with an ultraviolet light under an air atmosphere. Our experimental results implied that singlet oxygen was formed in the course of the reactions to oxidize the 1,4-dihydropyridazine molecules.
SYNTHETIC SPHINGOLIPID INSPIRED MOLECULES WITH HETEROAROMATIC APPENDAGES, METHODS OF THEIR SYNTHESIS AND METHODS OF TREATMENT
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Paragraph 0222, (2021/04/02)
Small molecules compounds and methods of their synthesis are provided. Formulations and medicaments are also provided that are directed to the treatment of disease, such as, for example, neoplasms, cancers, and other diseases. Therapeutics are also provided containing a therapeutically effective dose of one or more small molecule compounds, present either as pharmaceutically effective salt or in pure form, including, but not limited to, formulations for oral, intravenous, or intramuscular administration.
3,6-Substituted-1,2,4,5-tetrazines: Tuning reaction rates for staged labeling applications
Wang, Danzhu,Chen, Weixuan,Zheng, Yueqin,Dai, Chaofeng,Wang, Ke,Ke, Bowen,Wang, Binghe
, p. 3950 - 3955 (2014/06/09)
Cycloaddition reactions involving tetrazines have proven to be powerful bioorthogonal tools for various applications. Conceivably, sequential and selective labeling using tetrazine-based reactions can be achieved by tuning the reaction rate. By varying th
A general and efficient entry to asymmetric tetrazines for click chemistry applications
Wang, Danzhu,Chen, Weixuan,Zheng, Yueqin,Dai, Chaofeng,Wang, Lifang,Wang, Binghe
, p. 171 - 177 (2013/09/02)
The importance of click chemistry is widely recognized. Among all the known click reactions, those involving tetrazines represent the fastest click reactions reported and are generating a great deal of interest. However, there is no efficient entry to asymmetric tetrazines and those with strong electron withdrawing groups, which limits the development of this field. Herein, we report a general and efficient entry to asymmetric tetrazines with strongly electron withdrawing groups.
