173590-52-8Relevant academic research and scientific papers
trans-4-Methyl-3-imidazoyl pyrrolidine as a potent, highly selective histamine H3 receptor agonist in vivo
Shih, Neng-Yang,Aslanian, Robert,Lupo Jr., Andrew T.,Orlando, Steve,Piwinski, John J.,Green, Michael J.,Ganguly, Ashit K.,West, Robert,Tozzi, Salvatore,Kreutner, William,Hey, John A.
, p. 243 - 248 (2007/10/03)
Extensive structural modification of immepyr (+)-2 led to the dsiscovery of trans-4-methyl-3-imidazoyl pyrrolidine (±)-3a as a potent and highly selective H3 agonist. The pyrroline (±)-3a was resolved, and its (+) enantiomer, Sch 50971 [(+)-3a], showed a greater separation of H3 and H1 activities in vivo (H3/H1 ratio >> 330) than (R)-α-methylhistamine (+)-1 (H3/H1 ratio = 17), the standard H3 agonist.
