64464-34-2

Upstream product

• 64464-46-6 (1-trityl-1H-imidazol-4-yl)acetonitrile 
• 74-88-4 methyl iodide 

Downstream Products

• 173590-52-8 3-Cyano-3-methyl-3-(1-trityl-1H-imidazol-4-yl)-propionic acid methyl ester 
• 1001003-43-5 2-(1-trityl-1H-imidazol-4-yl)-propylamine 
• 151094-15-4 4-(3-Methyl-pyrrolidin-3-yl)-1-trityl-1H-imidazole 
• 151094-14-3 4-Methyl-4-(1-trityl-1H-imidazol-4-yl)-pyrrolidin-2-one 

Relevant academic research and scientific papers

NEW COMPOUNDS

The present invention encompasses compounds of general formula (1) wherein X and R1 to R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition having the above-mentioned properties.

trans-4-Methyl-3-imidazoyl pyrrolidine as a potent, highly selective histamine H3 receptor agonist in vivo

Extensive structural modification of immepyr (+)-2 led to the dsiscovery of trans-4-methyl-3-imidazoyl pyrrolidine (±)-3a as a potent and highly selective H3 agonist. The pyrroline (±)-3a was resolved, and its (+) enantiomer, Sch 50971 [(+)-3a], showed a greater separation of H3 and H1 activities in vivo (H3/H1 ratio >> 330) than (R)-α-methylhistamine (+)-1 (H3/H1 ratio = 17), the standard H3 agonist.