1736-10-3

Usage

Uses

Used in Pharmaceutical Industry:
Trifluoroacetic acid o-tolyl ester is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its high reactivity and compatibility with other chemicals make it an ideal candidate for the development of new drugs and the improvement of existing ones.
Used in Agrochemical Industry:
In the agrochemical industry, trifluoroacetic acid o-tolyl ester is utilized as a building block for the production of various agrochemicals. Its versatility and reactivity contribute to the development of effective and efficient pesticides and other agricultural chemicals.
Used in Specialty Chemicals Production:
Trifluoroacetic acid o-tolyl ester is employed as a crucial component in the manufacturing of specialty chemicals. Its unique properties and reactivity enable the creation of high-quality and specialized chemical products for various applications.
Used in Fine Chemicals Synthesis:
As an essential intermediate, trifluoroacetic acid o-tolyl ester is used in the synthesis of fine chemicals. Its ability to react with a wide range of other chemicals allows for the production of high-quality and specialized fine chemicals for various industries.

Upstream product

• 95-48-7 ortho-cresol 
• 407-25-0 trifluoroacetic anhydride 
• 108-88-3 toluene 
• 76-05-1 trifluoroacetic acid 
• 16656-82-9 lead (IV) trifluoroacetate 

Downstream Products

• 694-87-1 benzocyclobutene 
• 13630-19-8 2-methylbenzotrifluoride 
• 42908-77-0 1-methyl-2-(trifluoromethoxy)benzene 

Relevant academic research and scientific papers

Selectivity of the Aromatic Plumbylation Reaction

The plumbylation of toluene in dichloroacetic acid yields initially 5.4percent 2-, 1.8percent 3-, and 92.7percent 4-methylphenyllead(IV) dichloroacetates.The toluene to benzene rate ratio under these conditions is 59.9.The partial rate factors are oMef = 9.64, mMef = 3.21, pMef = 331.The plumbylation of toluene in trifluoroacetic acid yields aryl trifluoroacetates and biaryls.Analysis of these products suggest that the plumbylation reaction yields 17.9percent 2-, 3.2percent 3-, and 78.9percent 4-methylphenyllead (IV) trifluoroacetates in the initial step of the reaction.The toluene to benzene rate ratio is 114 under these conditions.The partial rate factors are oMef = 61.2, mMef = 10.8, and pMef = 540.These observations suggest that the plumbylation reaction is a typical electrophilic substitution and that the reaction is significantly more selective than thallation or mercuration.

OXIDATION BY THE SALTS OF METALS. VII. PLUMBATION AND OXIDATIVE SUBSTITUTION OF AROMATIC COMPOUNDS IN THE LEAD TETRAACETATE-LITHIUM CHLORIDE SYSTEM IN THE PRESENCE OF PERFLUORINATED CARBOXYLIC ACIDS

The oxidation of benzene and substituted benzenes PhX with electron-donating (X = CH3, OCH3) and electron-withdrawing (X = Hlg, CF3, NO2) substituents in the Pb(OAc)4-LiCl system was investigated in the presence of perfluorinated carboxylic acids RfCOOH (Rf = CF3, C6F13).The reaction leads to the plumbation, chlorination, and acyloxylation products.It was shown that the reactions take place through the formation of aryl derivatives of lead(IV) with the participation of mixed-ligand complexes of lead.The products from the plumbation of toluene (in C6F13COOH in the absence of lithium chloride) and benzotrifluoro were isolated.In trifluoroacetic acid these intermediates undergo intramolecular redox decomposition with ligand transfer.The halogenobenzenes and benzotrifluoride are oxidized selectively in the CF3COOH-Pb(IV)-LiCl system, giving the corresponding aryl chlorides with yields close to quantitative (80-90percent).