1736-24-9

Basic information

• Product Name: 4-Isoxazolecarboxylic acid, 5-(4-fluorophenyl)-3-methyl-
• Synonyms: 5-(4-fluorophenyl)-3-methylisoxazole-4-carboxylic acid;3-Methyl-4-carboxy-5-(4-fluor-phenyl)-isoxazol;5-(4-Fluoro-phenyl)-3-methyl-isoxazole-4-carboxylic acid
• CAS NO: 1736-24-9
• Molecular Formula: C11H8FNO3
• Molecular Weight: 221.188
• Mol File: 1736-24-9.mol
• Article Data: 1

Chemical Properties

• Melting Point: 191.5 - 192 °C (aq. ethanol)
• Boiling Point: 358.7±37.0 °C(Predicted)
• Density: 1.350±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 4-Isoxazolecarboxylic acid, 5-(4-fluorophenyl)-3-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Isoxazolecarboxylic acid, 5-(4-fluorophenyl)-3-methyl-(1736-24-9)
• EPA Substance Registry System: 4-Isoxazolecarboxylic acid, 5-(4-fluorophenyl)-3-methyl-(1736-24-9)

Safety Data

• Hazardous Substances Data: 1736-24-9(Hazardous Substances Data)

Upstream product

• 917388-54-6 C₁₂H₁₀FNO₃ 
• 146198-68-7 ethyl 2-(4-fluorobenzoyl)acetoacetate 
• 1644-03-7 5-(4-fluoro-phenyl)-3-methyl-isoxazole-4-carboxylic acid ethyl ester 

Relevant articles and documents

Aminoacetamide acyl guanidines as beta-secretase inhibitors

There is provided a series of substituted acyl guanidines of Formula (Ik) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R2, R3, R4, R5, R25, R26 and R27 as defined herein, their pharmaceutical compositions and methods of use. These compounds inhibit the processing of amyloid precursor protein (APP) by β-secretase and, more specifically, inhibit the production of Aβ-peptide. The present disclosure is directed to compounds useful in the treatment of neurological disorders related to β-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.