17360-31-5Relevant academic research and scientific papers
A simple proline-based organocatalyst for the enantioselective reduction of imines using trichlorosilane as a reductant
Kanemitsu, Takuya,Umehara, Atsushi,Haneji, Rieko,Nagata, Kazuhiro,Itoh, Takashi
, p. 3893 - 3898 (2012/07/02)
A simple and inexpensive proline-based organocatalyst was developed for the reduction of imines using trichlorosilane as a reductant. The reduction of N-aryl imines in the presence of 10 mol % of N-pivaloyl-l-proline anilide was carried out to give the co
Enantioselective addition of diethylzinc to aldehydes catalyzed by (S)-1-alkyl-2-(arylamino)methylpyrrolidine
Hosoda, Naoya,Ito, Hiroki,Takimoto, Tatsuya,Asami, Masatoshi
, p. 1014 - 1022 (2012/11/07)
Several chiral diamines, (S)-1-alkyl-2-(arylamino)methylpyrrolidine, were used as chiral catalysts for the enantioselective addition of diethylzinc to aldehydes. The best results were obtained by employing 0.15 equiv of (S)-2-anilinomethyl-1-benzylpyrrolidine, and chiral secondary alcohols were obtained with high enantiomeric excesses (up to 94% ee).
